Expression pattern of BMPs during chick limb development
العنوان: | Expression pattern of BMPs during chick limb development |
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المؤلفون: | Suresh Nimmagadda, Ruijin Huang, Poongodi Geetha-Loganathan, Martin Scaal, Bodo Christ |
المصدر: | Brain Structure and Function. 211:87-93 |
بيانات النشر: | Springer Science and Business Media LLC, 2006. |
سنة النشر: | 2006 |
مصطلحات موضوعية: | Embryology, Mesoderm, animal structures, Mesenchyme, Chick Embryo, In situ hybridization, Biology, Limb bud, Morphogenesis, medicine, Animals, Limb development, In Situ Hybridization, Regulation of gene expression, Gene Expression Profiling, Gene Expression Regulation, Developmental, Extremities, Cell Biology, Anatomy, medicine.anatomical_structure, Body plan, Zone of polarizing activity, Bone Morphogenetic Proteins, embryonic structures, Signal Transduction, Developmental Biology |
الوصف: | In vertebrates, BMPs (bone morphogenic proteins) play critical roles in establishing the basic embryonic body plan and are involved in the development of a large variety of organs and tissues. Here, we analyzed the expression pattern of various BMPs (2, 4, 5 and 7) by whole mount in situ hybridization during chick limb development. In limb, expression of BMPs suggests evolutionary conserved mechanisms of BMP-dependent differentiation between lower and higher vertebrates. During the early developmental stages, BMP-2 and BMP-7 are expressed in the posterior distal mesenchyme leaving a less prominent expression anteriorly. BMP-4 is initially expressed in the anterior mesenchyme and spreads later to the whole mesenchyme leaving a stronger expression at the anterior side. From HH-stage 25, expression of BMP-4 is observed in the anterior-posterior margins of the limb bud. The BMPs 2, 4 and 7 are expressed strongly in the AER, whereas BMP-5 is expressed as a weak signal in the distal mesoderm during the early stages of limb development. Later from HH-stage 25 onwards, BMP-5 is expressed in the dorsal and ventral muscular mass of the developing limb. As digits become identifiable, expression of BMPs are observed in the interdigital mesenchyme and can also be detected along the contours of the developing phalanges and at the distal tips of the digits. All these BMPs are found to be expressed in the developing feather buds from day 8 onwards. |
تدمد: | 1432-0568 0340-2061 |
DOI: | 10.1007/s00429-006-0129-6 |
URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5c06e7b333f56905b819c6ceb567793 https://doi.org/10.1007/s00429-006-0129-6 |
Rights: | CLOSED |
رقم الانضمام: | edsair.doi.dedup.....c5c06e7b333f56905b819c6ceb567793 |
قاعدة البيانات: | OpenAIRE |
تدمد: | 14320568 03402061 |
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DOI: | 10.1007/s00429-006-0129-6 |