Anti-Saccharomyces cerevisiaeAntibodies Are Elevated in Graves’ Disease But Not in Hashimoto’s Thyroiditis
| العنوان: | Anti-Saccharomyces cerevisiaeAntibodies Are Elevated in Graves’ Disease But Not in Hashimoto’s Thyroiditis |
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| المؤلفون: | Yosra Thabet, Wiem Manoubi, Achouak Achour, Amani Mankaï, Wahiba Sakly, Ibtissem Ghedira |
| المصدر: | Endocrine Research. 38:98-104 |
| بيانات النشر: | Informa UK Limited, 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Adult, Male, Tunisia, Adolescent, Graves' disease, Autoimmune thyroid disease, Hashimoto Disease, Saccharomyces cerevisiae, Thyroiditis, Young Adult, Endocrinology, medicine, Humans, In patient, Child, Antibodies, Fungal, Aged, biology, business.industry, General Medicine, Middle Aged, medicine.disease, Graves Disease, Immunoglobulin A, Immunoglobulin G, Immunology, biology.protein, Female, Antibody, business |
| الوصف: | Anti-Saccharomyces cerevisiae antibodies (ASCA) had been known to be specific for Crohn's disease, but they had also been found in many other autoimmune diseases.The aim of this study was to evaluate the prevalence of ASCA in patients with autoimmune thyroid disease (AITD).One hundred and ninety-seven patients with AITD and 160 healthy controls were included in the study. One hundred and nineteen patients had Graves' disease (GD) and 78 patients had Hashimoto's thyroiditis (HT). ASCA IgG and IgA were determined by ELISA.ASCA IgG were significantly more frequent in patients with GD than in control group (11.8% vs. 3.1%, p = 0.002). In HT, the frequency of ASCA IgG was similar to that of the control group (3.8% and 3.1% respectively). The frequency of ASCA IgA was similar in GD (0.8%), HT (2.6%), and the control group (3.1%). In all GD patients, the frequency of ASCA IgG was significantly higher than that of ASCA IgA (11.8% vs. 0.8%, p = 0.001). These results were also true even in male and female groups (10.4% vs. 1.3%, p = 0.01 and 14.3% vs. 0%, p = 0.01, respectively). ASCA IgG levels were significantly higher in GD patients (6.7 ± 11.1 vs. 2.2 ± 2.8, p = 3 × 10(-6)) and in HT patients (4.2 ± 4.7 vs. 2.2 ± 2.8, p = 0.0002) than those in the control group. ASCA IgA levels were comparable among patients with GD, HT, and the control group. In GD patients, the mean titer of ASCA IgG was significantly higher than that of ASCA IgA (6.7 ± 11.1 vs. 3.6 ± 4.2, p = 0.005).Patients with GD had a higher frequency of ASCA IgG than controls. |
| تدمد: | 1532-4206 0743-5800 |
| DOI: | 10.3109/07435800.2012.723293 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c50bb66279717b6fadb7886bc6f6581f https://doi.org/10.3109/07435800.2012.723293 |
| رقم الانضمام: | edsair.doi.dedup.....c50bb66279717b6fadb7886bc6f6581f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15324206 07435800 |
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| DOI: | 10.3109/07435800.2012.723293 |