Sequential Signaling Crosstalk Regulates Endomesoderm Segregation in Sea Urchin Embryos
| العنوان: | Sequential Signaling Crosstalk Regulates Endomesoderm Segregation in Sea Urchin Embryos |
|---|---|
| المؤلفون: | Lynne M. Angerer, Robert C. Angerer, Ryan C. Range, Aditya J. Sethi, Radhika M. Wikramanayake |
| المصدر: | Science. 335:590-593 |
| بيانات النشر: | American Association for the Advancement of Science (AAAS), 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Blastomeres, Mesoderm, Embryo, Nonmammalian, animal structures, Notch signaling pathway, Embryonic Development, Biology, Ligands, Article, Endomesoderm, medicine, Animals, Gene Regulatory Networks, Wnt Signaling Pathway, Transcription factor, beta Catenin, Multidisciplinary, Receptors, Notch, Endoderm, Gastrulation, Embryogenesis, Wnt signaling pathway, Gene Expression Regulation, Developmental, Anatomy, Blastula, Cell biology, Wnt Proteins, medicine.anatomical_structure, Sea Urchins, embryonic structures, TCF Transcription Factors, Signal Transduction, Transcription Factors |
| الوصف: | The segregation of embryonic endomesoderm into separate endoderm and mesoderm fates is not well understood in deuterostomes. Using sea urchin embryos, we showed that Notch signaling initiates segregation of the endomesoderm precursor field by inhibiting expression of a key endoderm transcription factor in presumptive mesoderm. The regulatory circuit activated by this transcription factor subsequently maintains transcription of a canonical Wnt (cWnt) ligand only in endoderm precursors. This cWnt ligand reinforces the endoderm state, amplifying the distinction between emerging endoderm and mesoderm. Before gastrulation, Notch-dependent nuclear export of an essential β-catenin transcriptional coactivator from mesoderm renders it refractory to cWnt signals, insulating it against an endoderm fate. Thus, we report that endomesoderm segregation is a progressive process, requiring a succession of regulatory interactions between cWnt and Notch signaling. |
| تدمد: | 1095-9203 0036-8075 |
| DOI: | 10.1126/science.1212867 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4a7c3846c0ff991ad3527ed2a7c9179 https://doi.org/10.1126/science.1212867 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....c4a7c3846c0ff991ad3527ed2a7c9179 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10959203 00368075 |
|---|---|
| DOI: | 10.1126/science.1212867 |