Intravenous iron and recombinant erythropoietin for the treatment of postoperative anemia
| العنوان: | Intravenous iron and recombinant erythropoietin for the treatment of postoperative anemia |
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| المؤلفون: | Mohammed Ghannam, Ian Quirt, Stuart A. McCluskey, Keyvan Karkouti, Terrence M. Yau, Mary-Jane Salpeter |
| المصدر: | Canadian Journal of Anesthesia/Journal canadien d'anesthésie. 53:11-19 |
| بيانات النشر: | Springer Science and Business Media LLC, 2006. |
| سنة النشر: | 2006 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Time Factors, Anemia, Iron sucrose, Ferric Compounds, law.invention, Glucaric Acid, Hemoglobins, Double-Blind Method, Randomized controlled trial, Reticulocyte, law, medicine, Humans, Orthopedic Procedures, Cardiac Surgical Procedures, Erythropoietin, Ferric Oxide, Saccharated, Postoperative Care, Analysis of Variance, business.industry, General Medicine, Middle Aged, medicine.disease, Recombinant Proteins, Red blood cell, Treatment Outcome, Anesthesiology and Pain Medicine, medicine.anatomical_structure, Anesthesia, Injections, Intravenous, Orthopedic surgery, Drug Therapy, Combination, Female, Hemoglobin, business, medicine.drug |
| الوصف: | To determine if early recovery from severe post-operative anemia is accelerated by iv iron therapy alone or in combination with recombinant erythropoietin (EPO).In this double-blinded, placebo-controlled randomized study, consenting adult patients without preoperative anemia whose hemoglobin concentration (Hb) was 70 to 90 g x L(-1) on the first day after cardiac or orthopedic surgery (POD 1) were assigned to one of three groups: control, iv iron alone (200 mg of iron sucrose on POD 1, 2, and 3) or in combination with EPO (600 U x kg(-1) on POD 1 and 3). The primary outcome was increase in Hb (adjusted for red blood cell transfusions) from POD 1 to 7. Analysis was by intention-to-treat in patients for whom the primary outcome was available. Group effect was analyzed by the ANOVA test, and between-group differences were specified with a Duncan multiple-range test.The primary outcome was available in 31 of 38 randomized patients. The average POD 1 Hb was 84 +/- 4 g x L(-1). There were no between-group differences in outcomes except for higher reticulocyte counts on POD-7 in the combination group. The average adjusted one-week increases in Hb were 7 +/- 8 g x L(-1) in the control group (n = 10), 9 +/- 9 g x L(-1) in the iv iron group (n = 11), and 10 +/- 14 g x L(-1) in the combination group (n = 10). The average adjusted six-week increases in Hb were 37 +/- 14 g x L(-1) in the control group, 40 +/- 7 g x L(-1) in the iv iron group, and 45 +/- 12 g x L(-1) in the combination group.Early postoperative treatment with iv iron alone or in combination with EPO does not appear to accelerate early recovery from postoperative anemia. |
| تدمد: | 1496-8975 0832-610X |
| DOI: | 10.1007/bf03021522 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c37e6bd3edbd8b99f94c38db83f5c118 https://doi.org/10.1007/bf03021522 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....c37e6bd3edbd8b99f94c38db83f5c118 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14968975 0832610X |
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| DOI: | 10.1007/bf03021522 |