Targeting HDACs: a promising therapy for Alzheimer's disease
| العنوان: | Targeting HDACs: a promising therapy for Alzheimer's disease |
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| المؤلفون: | Xueling Dai, Han-Chang Huang, Zhao-Feng Jiang, Ke Xu |
| المصدر: | Oxidative Medicine and Cellular Longevity Oxidative Medicine and Cellular Longevity, Vol 2011 (2011) |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | Aging, Review Article, Biochemistry, Histone Deacetylases, Alzheimer Disease, medicine, Humans, Protein Isoforms, Epigenetics, lcsh:QH573-671, Genetics, Histone deacetylase 5, biology, lcsh:Cytology, Histone deacetylase 2, HDAC11, Cell Biology, General Medicine, medicine.disease, Histone Deacetylase Inhibitors, Histone, Acetylation, biology.protein, Histone deacetylase, Alzheimer's disease, Neuroscience |
| الوصف: | Epigenetic modifications like DNA methylation and histone acetylation play an important role in a wide range of brain disorders. Histone deacetylases (HDACs) regulate the homeostasis of histone acetylation. Histone deacetylase inhibitors, which initially were used as anticancer drugs, are recently suggested to act as neuroprotectors by enhancing synaptic plasticity and learning and memory in a wide range of neurodegenerative and psychiatric disorders, such as Alzheimer's disease (AD) and Parkinson's disease (PD). To reveal the physiological roles of HDACs may provide us with a new perspective to understand the mechanism of AD and to develop selective HDAC inhibitors. This paper focuses on the recent research progresses of HDAC proteins and their inhibitors on the roles of the treatment for AD. |
| تدمد: | 1942-0994 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c27e37394a8bfb5063fffaa321bd5aad https://pubmed.ncbi.nlm.nih.gov/21941604 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....c27e37394a8bfb5063fffaa321bd5aad |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19420994 |
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