Short-term efficacy and safety of oral and nasal corticosteroids in covid-19 patients with olfactory dysfunction: A European multicenter study
| العنوان: | Short-term efficacy and safety of oral and nasal corticosteroids in covid-19 patients with olfactory dysfunction: A European multicenter study |
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| المؤلفون: | Giovanni Salzano, Philippe Boelpaep, Serge-D Le Bon, Jerome R. Lechien, Luigi Angelo Vaira, Mohamad Khalife, Giacomo De Riu, Giovanna Deiana, Carlos M. Chiesa-Estomba, Mihaela Horoi, Sven Saussez, Stéphane Hans, Marzia Petrocelli, Claire Hopkins |
| المساهمون: | Université de Versailles Saint-Quentin-en-Yvelines - UFR Sciences de la santé Simone Veil (UVSQ Santé), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ) |
| المصدر: | Pathogens Pathogens, MDPI, 2021, 10 (6), ⟨10.3390/pathogens10060698⟩ Pathogens, Vol 10, Iss 698, p 698 (2021) Pathogens, 10 (6 Pathogens; Volume 10; Issue 6; Pages: 698 |
| بيانات النشر: | HAL CCSD, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Microbiology (medical), medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Anosmia, [SDV]Life Sciences [q-bio], Article, law.invention, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, law, Internal medicine, Immunology and Allergy, Medicine, In patient, 030223 otorhinolaryngology, Molecular Biology, General Immunology and Microbiology, business.industry, SARS-CoV-2, COVID-19, anosmia, olfactory, smell, treatment, Généralités, Parosmia, 3. Good health, Smell, Treatment, Infectious Diseases, Multicenter study, 030220 oncology & carcinogenesis, medicine.symptom, business, After treatment, Olfactory |
| الوصف: | Background: The objective of this study was to investigate the efficacy and safety of early administration of oral corticosteroids (OC) or nasal corticosteroids (NC) as an add-on to olfactory training (OT) versus OT alone in patients with olfactory dysfunction (OD) related to coronavirus disease 2019 (COVID-19). Methods: Patients with a positive diagnosis of COVID-19 and OD were prospectively recruited from March 22 to December 15, 2020 from 4 European hospitals. Patients had confirmed OD on psychophysical testing. All patients undertook OT, with add-on 10 days of OC (group 1: OC + OT), or 1 month of NC (group 2: NC + OT) or olfactory training alone (group 3: OT). Olfactory evaluations (Sniffin’Sticks tests) were carried out at the time of inclusion, 1 and 2 months after the start of the therapeutic course. Results: A total of 152 hyposmic or anosmic patients completed the study. Group 1, 2 and 3 included 59, 22 and 71 patients, respectively and all patient groups were comparable regarding baseline Sniffin’Sticks tests. The median Sniffin’Sticks test values significantly improved from pre-to post-intervention in all groups. The increase of Sniffin’Sticks test values was higher in group 1 (OC + OT) compared with groups 2 and 3 (p < 0.001) at one month after treatment but did not remain so at 2 months. Groups 1, 2 and 3, respectively, presented parosmia in 20/71 (28.2%), 9/22 (40.9%) and 42/71 (59.2%) patients. This difference was statistically significant between group 1 and 3 (p < 0.001). There were no patients with a worsening of the disease or an increase of the severity of the COVID-19 symptoms. Conclusions: The use of OCs in patients with OD related to mild COVID-19 is generally well-tolerated without any case of deterioration of symptoms. OC is associated with greater improvement in psychophysical olfactory evaluations at 1-month post-treatment but there was no difference at 2 months. Parosmia may be reduced following treatment with OC and NC. On the basis of these preliminary results, it is possible to state that considering the 2 months efficacy of OC and NC with respect to the OT alone and the risk-benefit ratio, the benefit to start a specific treatment of COVID-19 related OD cannot be demonstrated and there is a need for a randomised controlled trial to assess this further. SCOPUS: ar.j info:eu-repo/semantics/published |
| وصف الملف: | 1 full-text file(s): application/pdf; application/pdf |
| اللغة: | English |
| تدمد: | 2076-0817 |
| DOI: | 10.3390/pathogens10060698⟩ |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c277537fb7e8b5bc354ff64d30b2a039 https://hal.archives-ouvertes.fr/hal-03287327 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....c277537fb7e8b5bc354ff64d30b2a039 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20760817 |
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| DOI: | 10.3390/pathogens10060698⟩ |