Association of mutations in the core promoter and precore region of hepatitis virus with fulminant and severe acute hepatitis in Japan
| العنوان: | Association of mutations in the core promoter and precore region of hepatitis virus with fulminant and severe acute hepatitis in Japan |
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| المؤلفون: | Michiaki Koga, Tatsuya Fujino, Osami Inoue, Yuji Kato, Tomoyuki Aritomi, Hiroshi Yatsuhashi, Michitami Yano, Kazumi Yamasaki |
| المصدر: | Journal of Gastroenterology and Hepatology. 13:1125-1132 |
| بيانات النشر: | Wiley, 1998. |
| سنة النشر: | 1998 |
| مصطلحات موضوعية: | Adult, Male, Hepatitis B virus, Fulminant, DNA Mutational Analysis, medicine.disease_cause, Polymerase Chain Reaction, Sensitivity and Specificity, Immunoenzyme Techniques, Liver disease, Japan, Orthohepadnavirus, medicine, Humans, Point Mutation, Hepatitis B e Antigens, Hepatitis B Antibodies, Promoter Regions, Genetic, Fulminant hepatitis, Aged, Hepatitis, Chi-Square Distribution, Hepatology, biology, business.industry, Point mutation, Gastroenterology, Middle Aged, Hepatitis B, medicine.disease, biology.organism_classification, Virology, Hepadnaviridae, Acute Disease, DNA, Viral, Immunology, Female, business |
| الوصف: | It was recently reported that mutations in the precore and core promoter region of hepatitis B virus (HBV) are associated with fulminant hepatitis. The aim of this study was to investigate the association of mutations in the precore and core promoter region of HBV with fulminant and severe acute hepatitis. We studied Japanese patients with acute HBV infection, including seven patients with fulminant hepatitis, 12 with severe acute hepatitis and 41 with acute self-limited hepatitis. The presence of HBV mutants was examined by using a point mutation assay to detect a G to A transition at position 1896 in the precore region and an A to T transition at position 1762 and a G to A transition at position 1764 in the core promoter region. Significant differences in the proportion of mutations in the precore or core promoter region were present between patients with fulminant hepatitis and self-limited acute hepatitis (7/7 (100%) vs 4/41 (9.8%), P < 0.01) and between severe acute hepatitis and self-limited acute hepatitis (6/12 (50.0%) vs 4/41 (9.8%), P < 0.01). The frequency of mutation increased proportionately with the severity of disease in patients with acute HBV infection. Fulminant hepatitis B in Japan is closely associated with mutations in the core promoter and precore gene of HBV. Point mutation assays for HBV precore and core promoter analysis may be useful to predict the outcome of liver disease in patients with acute HBV infection. |
| تدمد: | 1440-1746 0815-9319 |
| DOI: | 10.1111/j.1440-1746.1998.tb00588.x |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c204b6cbab4461ac2cd6b10d1174ab0e https://doi.org/10.1111/j.1440-1746.1998.tb00588.x |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....c204b6cbab4461ac2cd6b10d1174ab0e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14401746 08159319 |
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| DOI: | 10.1111/j.1440-1746.1998.tb00588.x |