Cardiovascular disease in chronic myelomonocytic leukemia: do monocytosis and chronic inflammation predispose to accelerated atherosclerosis?
| العنوان: | Cardiovascular disease in chronic myelomonocytic leukemia: do monocytosis and chronic inflammation predispose to accelerated atherosclerosis? |
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| المؤلفون: | Anders Lindholm Sørensen, Hans Carl Hasselbalch, Mette Vestergaard Elbæk |
| المصدر: | Annals of Hematology. 98:101-109 |
| بيانات النشر: | Springer Science and Business Media LLC, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Chronic lymphocytic leukemia, Chronic myelomonocytic leukemia, Inflammation, Disease, 03 medical and health sciences, 0302 clinical medicine, Monocytosis, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, hemic and lymphatic diseases, Internal medicine, medicine, Humans, Aged, Retrospective Studies, Aged, 80 and over, Accelerated atherosclerosis, Hematology, business.industry, Retrospective cohort study, General Medicine, Middle Aged, Atherosclerosis, medicine.disease, 030220 oncology & carcinogenesis, Female, medicine.symptom, business, 030215 immunology |
| الوصف: | Patients with chronic myelomonocytic leukemia (CMML) have monocytosis and likely a state of chronic inflammation. Both have been associated with an increased risk of atherosclerosis. The aim of the study was to test the hypothesis that CMML patients are at increased risk of developing cardiovascular disease (CVD) due to persistent monocytosis and sustained chronic inflammation. In a retrospective cohort study, we assessed hazards for cardiovascular events after diagnosis in 112 CMML patients and 231 chronic lymphocytic leukemia (CLL) patients. Analyses were carried out on restricted cohorts (CMML = 84, CLL = 186), excluding patients with a prior history of CVD, as well as on unrestricted cohorts. In the restricted cohorts, a significant effect of cardiovascular event occurrence did not remain after adjustment (HR 2.49, 95% CI 0.94-6.60). In unrestricted cohorts, we found a more than twofold increased rate of cardiovascular events in CMML (HR 2.34, 95% CI 1.05-5.20). Our results indicate an increased risk of CVD after the diagnosis in CMML patients. |
| تدمد: | 1432-0584 0939-5555 |
| DOI: | 10.1007/s00277-018-3489-0 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1ef692a4fe569bd664581e5d0f77151 https://doi.org/10.1007/s00277-018-3489-0 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....c1ef692a4fe569bd664581e5d0f77151 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14320584 09395555 |
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| DOI: | 10.1007/s00277-018-3489-0 |