Risk factors for poor neonatal adaptation after exposure to antidepressants in utero
| العنوان: | Risk factors for poor neonatal adaptation after exposure to antidepressants in utero |
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| المؤلفون: | Noera Kieviet, Hanneke Wennink, Adriaan Honig, Chris Hoppenbrouwers, Koert M. Dolman, Johannes Berkhof |
| المساهمون: | Pediatric surgery, Epidemiology and Data Science, Psychiatry, EMGO - Mental health |
| المصدر: | Kieviet, N, Hoppenbrouwers, C J C, Dolman, K M, Berkhof, J, Wennink, H & Honig, A 2015, ' Risk factors for poor neonatal adaptation after exposure to antidepressants in utero ', Acta Paediatrica, vol. 104, no. 4, pp. 384-391 . https://doi.org/10.1111/apa.12921 Acta Paediatrica, 104(4), 384-391. Wiley-Blackwell |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Breastfeeding, Formula feeding, Pregnancy, Risk Factors, Adaptation, Psychological, medicine, Humans, Depression (differential diagnoses), Obstetrics, business.industry, musculoskeletal, neural, and ocular physiology, Infant, Newborn, General Medicine, Antidepressive Agents, In utero, Prenatal Exposure Delayed Effects, Anesthesia, biological sciences, Pediatrics, Perinatology and Child Health, cardiovascular system, Anxiety, Antidepressant, Female, Serotonin, medicine.symptom, business, tissues, Cohort study |
| الوصف: | Aim Infants exposed to antidepressants in utero are at risk of developing poor neonatal adaptation (PNA). This study identified risk factors for PNA. Methods In this cohort study, data on mothers and infants admitted to the maternity ward of a general hospital between 2007 and 2012 were analysed. All infants were exposed to an antidepressant during the last trimester of foetal life. The main outcome measure was PNA, defined as at least one Finnegan scores of four or more during admission. Risk factors analysed for their possible association with PNA included type of feeding, type and dosage of antidepressant, prematurity and maternal smoking, anxiety and depression. Results We included 247 infants in the study and 157 (64%) developed PNA. Formula feeding was associated with an increased risk of PNA compared to breastfeeding or mixed feeding (OR 3.16 95% CI 1.40–7.13 p = 0.003). Selective serotonin reuptake inhibitors (SSRIs) were associated with an increased risk of PNA compared to serotonin and noradrenaline reuptake inhibitors (OR 2.52 95% CI 1.07–5.95 p = 0.04). Dosage did not influence the risk of PNA (OR 1.50 95% CI 0.89–2.52 p = 0.13). Conclusion Formula feeding and exposure to SSRIs were associated with development of PNA, but dosage was not. |
| تدمد: | 0803-5253 |
| DOI: | 10.1111/apa.12921 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1e11a4aaeffc13edfa18b4cd53c0208 https://research.vumc.nl/en/publications/b3aa2269-41e8-4705-929f-2ca7af0867ad |
| Rights: | RESTRICTED |
| رقم الانضمام: | edsair.doi.dedup.....c1e11a4aaeffc13edfa18b4cd53c0208 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 08035253 |
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| DOI: | 10.1111/apa.12921 |