Functionalized Gold Nanoparticles as Contrast Agents for Proton and Dual Proton/Fluorine MRI
| العنوان: | Functionalized Gold Nanoparticles as Contrast Agents for Proton and Dual Proton/Fluorine MRI |
|---|---|
| المؤلفون: | Domenico Aquino, Maria Şologan, Mariangela Boccalon, Isabella Giachetti, Lucia Pasquato, Paolo Pengo, Francesco Padelli, Gianpiero Adami |
| المساهمون: | Şologan, Maria, Padelli, Francesco, Giachetti, Isabella, Aquino, Domenico, Boccalon, Mariangela, Adami, Gianpiero, Pengo, Paolo, Pasquato, Lucia |
| المصدر: | Nanomaterials Nanomaterials, Vol 9, Iss 6, p 879 (2019) Volume 9 Issue 6 |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Materials science, General Chemical Engineering, Gadolinium, chemistry.chemical_element, Nanoparticle, 19F MRI, Imaging phantom, Article, lcsh:Chemistry, Nuclear magnetic resonance, hybrid organic-inorganic nanoparticles, fluorine, Monolayer, medicine, fluorinated monolayers, magnetic resonance imaging, General Materials Science, Chelation, contrast agents, hybrid organic-inorganic nanoparticle, gadolinium, medicine.diagnostic_test, Spin–lattice relaxation, Magnetic resonance imaging, contrast agent, fluorinated monolayer, chemistry, lcsh:QD1-999, Colloidal gold |
| الوصف: | Gold nanoparticles carrying fluorinated ligands in their monolayer are, by themselves, contrast agents for 19F magnetic resonance imaging displaying high sensitivity because of the high density of fluorine nuclei achievable by grafting suitable ligands on the gold core surface. Functionalization of these nanoparticles with Gd(III) chelates allows adding a further functional activity to these systems, developing materials also acting as contrast agents for proton magnetic resonance imaging. These dual mode contrast agents may allow capitalizing on the benefits of 1H and 19F magnetic resonance imaging in a single diagnostic session. In this work, we describe a proof of principle of this approach by studying these nanoparticles in a high field preclinical scanner. The Gd(III) centers within the nanoparticles monolayer shorten considerably the 19F T1 of the ligands but, nevertheless, these systems display strong and sharp NMR signals which allow recording good quality 19F MRI phantom images at nanoparticle concentration of 20 mg/mL after proper adjustment of the imaging sequence. The Gd(III) centers also influence the T1 relaxation time of the water protons and high quality 1H MRI images could be obtained. Gold nanoparticles protected by hydrogenated ligands and decorated with Gd(III) chelates are reported for comparison as 1H MRI contrast agents. |
| وصف الملف: | application/pdf; ELETTRONICO |
| اللغة: | English |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1c0aeb1c04bee30f736b8e7e30afc1c http://hdl.handle.net/11368/2944851 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....c1c0aeb1c04bee30f736b8e7e30afc1c |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |