The RhoA dependent anti-metastatic function of RKIP in breast cancer
| العنوان: | The RhoA dependent anti-metastatic function of RKIP in breast cancer |
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| المؤلفون: | Alexandria LaSalla, Vu N. Bach, Julius N. De Castro, Hussain N. Odeh, Christopher Figy, Rafael Garcia-Mata, Clariza Borile, Miranda Yeung, Gardiyawasam Kalpana, Jingwei Feng, Claire Tipton, Kam C. Yeung |
| المصدر: | Scientific Reports Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021) |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Cell biology, RHOA, Molecular biology, Science, Apoptosis, Breast Neoplasms, Phosphatidylethanolamine Binding Protein, Biochemistry, CCL5, Article, Metastasis, Mice, medicine, Genetics, Biomarkers, Tumor, Tumor Cells, Cultured, Animals, Humans, Cancer, Cell Proliferation, Multidisciplinary, biology, Kinase, Chemistry, Inhibitor protein, Actin cytoskeleton, medicine.disease, Xenograft Model Antitumor Assays, Gene Expression Regulation, Neoplastic, Cancer cell, biology.protein, Cancer research, Medicine, Female, rhoA GTP-Binding Protein, Function (biology) |
| الوصف: | Raf-1 kinase inhibitor protein was initially discovered as a physiological kinase inhibitor of the MAPK signaling pathway and was later shown to suppress cancer cell invasion and metastasis. Yet, the molecular mechanism through which RKIP executes its effects is not completely defined. RhoA has both a pro- and anti-metastatic cell-context dependent functions. Given that Rho GTPases primarily function on actin cytoskeleton dynamics and cell movement regulation, it is possible that one way RKIP hinders cancer cell invasion/metastasis is by targeting these proteins. Here we show that RKIP inhibits cancer cell invasion and metastasis by stimulating RhoA anti-tumorigenic functions. Mechanistically, RKIP activates RhoA in an Erk2 and GEF-H1 dependent manner to enhance E-cadherin membrane localization and inhibit CCL5 expression. |
| تدمد: | 2045-2322 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c19f67ce6897cfdbea5c1777948e2f2e https://pubmed.ncbi.nlm.nih.gov/34465801 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....c19f67ce6897cfdbea5c1777948e2f2e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20452322 |
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