The pathophysiology of major depressive disorder through the lens of systems biology: Network analysis of the psycho-immune-neuroendocrine physiome
| العنوان: | The pathophysiology of major depressive disorder through the lens of systems biology: Network analysis of the psycho-immune-neuroendocrine physiome |
|---|---|
| المؤلفون: | Nicolas J.C. Stapelberg, Tuan A. Bui, Verena Mansour, Susannah Johnson, Grace Branjerdporn, Sam Adhikary, Kevin Ashton, Nevin Taylor, John P. Headrick |
| المصدر: | Journal of Neuroimmunology. 372:577959 |
| بيانات النشر: | Elsevier BV, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Patient-Specific Modeling, Depressive Disorder, Major, Neurology, Corticotropin-Releasing Hormone, Interleukin-6, Systems Biology, Immunology, Humans, Immunology and Allergy, Neurology (clinical), Glucocorticoids |
| الوصف: | The psycho-immune-neuroendocrine (PINE) network is a predominantly physiological (metabolomic) model constructed from the literature, inter-linking multiple biological processes associated with major depressive disorder (MDD), thereby integrating putative mechanistic pathways for MDD into a single network.Previously published metabolomic pathways for the PINE network based on literature searches conducted in 1991-2021 were used to construct an edge table summarizing all physiological pathways in pairs of origin nodes and target nodes. The Gephi software program was used to calculate network metrics from the edge table, including total degree and centrality measures, to ascertain key network nodes and construct a directed network graph.An edge table and directional network graph of physiological relationships in the PINE network is presented. The network has properties consistent with complex biological systems, with analysis yielding key network nodes comprising pro-inflammatory cytokines (TNF- α, IL6 and IL1), glucocorticoids and corticotropin releasing hormone (CRH). These may represent central structural and regulatory elements in the context of MDD.The identified hubs have a high degree of connection and are known to play roles in the progression from health to MDD. These nodes represent strategic targets for therapeutic intervention or prevention. Future work is required to build a weighted and dynamic simulation of the network PINE. |
| تدمد: | 0165-5728 1991-2021 |
| DOI: | 10.1016/j.jneuroim.2022.577959 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c10c72906122655b5fba999169d564c4 https://doi.org/10.1016/j.jneuroim.2022.577959 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....c10c72906122655b5fba999169d564c4 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 01655728 19912021 |
|---|---|
| DOI: | 10.1016/j.jneuroim.2022.577959 |