AIEgen-coupled upconversion nanoparticles eradicate solid tumors through dual-mode ROS activation
| العنوان: | AIEgen-coupled upconversion nanoparticles eradicate solid tumors through dual-mode ROS activation |
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| المؤلفون: | Wenbo Wu, Xiaogang Liu, Bin Liu, Kenry, Zichao Luo, Zhigao Yi, Shidang Xu, Zhihong Wang, Deling Kong, Duo Mao, Fang Hu, Shuangqian Yan |
| المصدر: | Science Advances |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | T cell, medicine.medical_treatment, Antigen presentation, Materials Science, 02 engineering and technology, 03 medical and health sciences, Immune system, Antigen, Cell Line, Tumor, Neoplasms, medicine, Humans, Research Articles, 030304 developmental biology, chemistry.chemical_classification, 0303 health sciences, Reactive oxygen species, Multidisciplinary, SciAdv r-articles, Life Sciences, Immunotherapy, 021001 nanoscience & nanotechnology, medicine.anatomical_structure, chemistry, Cancer research, Immunogenic cell death, Nanoparticles, Lymph, 0210 nano-technology, Reactive Oxygen Species, Research Article |
| الوصف: | Integration of AIEgens with upconversion nanoparticles inhibits tumor recurrence and metastasis. Reactive oxygen species (ROS) are essential for the regulation of antitumor immune responses, where they could induce immunogenic cell death, promote antigen presentation, and activate immune cells. Here, we report the development of near-infrared (NIR)–driven immunostimulants, based on coupling upconversion nanoparticles with aggregation-induced emission luminogens (AIEgens), to integrate the immunological effects of ROS for enhanced adaptive antitumor immune responses. Intratumorally injected AIEgen-upconversion nanoparticles produce high-dose ROS under high-power NIR irradiation, which induces immunogenic cell death and antigen release. These nanoparticles can also capture the released antigens and deliver them to lymph nodes. Upon subsequent low-power NIR treatment of lymph nodes, low-dose ROS are generated to further trigger efficient T cell immune responses through activation of dendritic cells, preventing both local tumor recurrence and distant tumor growth. The utility of dual-mode pumping power on AIEgen-coupled upconversion nanoparticles offers a powerful and controllable platform to activate adaptive immune systems for tumor immunotherapy. |
| تدمد: | 2375-2548 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0d84da0866b1482e8697ccdf304ad10 https://pubmed.ncbi.nlm.nih.gov/32637621 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....c0d84da0866b1482e8697ccdf304ad10 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 23752548 |
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