Linking a mutation to survival in wild mice
| العنوان: | Linking a mutation to survival in wild mice |
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| المؤلفون: | Charles C.Y. Xu, Ricardo Mallarino, Matthieu Foll, Hopi E. Hoekstra, Jeffrey D. Jensen, Susanne P. Pfeifer, Kazumasa Wakamatsu, Stefan Laurent, Rowan D. H. Barrett, Jonathan S. Duke-Cohan |
| المصدر: | Science. 363:499-504 |
| بيانات النشر: | American Association for the Advancement of Science (AAAS), 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0106 biological sciences, 0301 basic medicine, Coat, Peromyscus, Genotype, Population, Mice, Transgenic, Locus (genetics), 010603 evolutionary biology, 01 natural sciences, 03 medical and health sciences, Gene Frequency, Animals, Selection, Genetic, Hair Color, education, Allele frequency, Sequence Deletion, Melanins, Genetics, education.field_of_study, Multidisciplinary, Natural selection, biology, Pigmentation, Nebraska, biology.organism_classification, Phenotype, Mice, Inbred C57BL, 030104 developmental biology, Mutation, Agouti Signaling Protein, sense organs |
| الوصف: | Adaptive evolution in new or changing environments can be difficult to predict because the functional connections between genotype, phenotype, and fitness are complex. Here, we make these explicit connections by combining field and laboratory experiments in wild mice. We first directly estimate natural selection on pigmentation traits and an underlying pigment locus, Agouti, by using experimental enclosures of mice on different soil colors. Next, we show how a mutation in Agouti associated with survival causes lighter coat color through changes in its protein binding properties. Together, our findings demonstrate how a sequence variant alters phenotype and then reveal the ensuing ecological consequences that drive changes in population allele frequency, thereby illuminating the process of evolution by natural selection. |
| تدمد: | 1095-9203 0036-8075 |
| DOI: | 10.1126/science.aav3824 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c01c9162535eb992a80e3853f8a55802 https://doi.org/10.1126/science.aav3824 |
| رقم الانضمام: | edsair.doi.dedup.....c01c9162535eb992a80e3853f8a55802 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10959203 00368075 |
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| DOI: | 10.1126/science.aav3824 |