Tumor characteristics and detection method in the MRISC screening program for the early detection of hereditary breast cancer
| العنوان: | Tumor characteristics and detection method in the MRISC screening program for the early detection of hereditary breast cancer |
|---|---|
| المؤلفون: | Nicoline Hoogerbrugge, Sybren L. Meijer, H.J. de Koning, Jan C. Oosterwijk, Theo Kok, Carla Boetes, H. M. Zonderland, A. P. E. Besnard, Caroline Seynaeve, Inge Marie Obdeijn, R. A. Manoliu, Mieke Kriege, Hans Peterse, Madeleine M. A. Tilanus-Linthorst, Sara H. Muller, E.J.T. Rutgers, C.C.M. Bartels, J.G.M. Klijn, C.T.M. Brekelmans, Rob A. E. M. Tollenaar |
| المساهمون: | Radiology and Nuclear Medicine, Pathology, Medical Oncology, Radiology & Nuclear Medicine, Surgery, Internal Medicine, Public Health, Faculteit Medische Wetenschappen/UMCG, Damage and Repair in Cancer Development and Cancer Treatment (DARE), Targeted Gynaecologic Oncology (TARGON) |
| المصدر: | Breast cancer research and treatment, 102(3), 357-363. Springer New York Breast Cancer Research and Treatment, 102(3), 357-363. Springer New York Breast Cancer Research and Treatment, 102, 357-63 Breast Cancer Research and Treatment, 102(3), 357-363. SPRINGER Breast Cancer Research and Treatment, 102, 3, pp. 357-63 |
| بيانات النشر: | Springer Science and Business Media LLC, 2006. |
| سنة النشر: | 2006 |
| مصطلحات موضوعية: | Cancer Research, Pathology, Genetics and epigenetic pathways of disease [NCMLS 6], SURGERY, HIGH FAMILIAL RISK, tumorcharacteristics, Epidemiology, Mass Screening, MR MAMMOGRAPHY, ULTRASOUND, Molecular diagnosis, prognosis and monitoring [UMCN 1.2], inherited risk, medicine.diagnostic_test, WOMEN, Magnetic Resonance Imaging, Oncology, Invasive lobular carcinoma, Female, Radiology, MRI, medicine.medical_specialty, Tumor suppressor gene, mammography, Early detection, Breast Neoplasms, MUTATION CARRIERS, DIAGNOSIS, Sensitivity and Specificity, INVASIVE LOBULAR CARCINOMA, Molecular epidemiology [NCEBP 1], breast cancer, Breast cancer, SDG 3 - Good Health and Well-being, Translational research [ONCOL 3], SURVEILLANCE, medicine, Humans, Mammography, Genetic Predisposition to Disease, Risk factor, Hereditary cancer and cancer-related syndromes [ONCOL 1], business.industry, screening, MAMMOGRAPHIC FINDINGS, Histology, BRCA1, medicine.disease, BRCA2, Early Diagnosis, business |
| الوصف: | In the MRISC study, women with an inherited risk for breast cancer were screened by a 6-month clinical breast examination (CBE) and yearly MRI and mammography. We found that the MRISC screening scheme could facilitate early breast cancer diagnosis and that MRI was a more sensitive screening method than mammography, but less specific. In the current study we investigated the contribution of MRI in the early detection of breast cancer in relation to␣tumor characteristics. From November 1999 to October 2003, 1909 women were included and 50 breast cancers were detected, of which 45 were evaluable and included in the current study. We compared the characteristics of tumors detected by MRI-only with those of all other (non-palpable) screen-detected tumors. Further, we compared the sensitivity of mammography and MRI within subgroups according to different tumor characteristics. Twenty-two (49%) of the 45 breast cancers were detected by MRI and not visible at mammography, of which 20 (44%) were also not palpable (MRI-only detected tumors). MRI-only detected tumors were more often node-negative than other screen-detected cancers (94 vs. 59%; P = 0.02) and tended to be more often ≤1 cm (58 vs. 31%; P = 0.11). MRI was more sensitive than mammography for a wide spectrum of invasive tumor characteristics i.e., size, nodal status, histology, grade and ER status. Half of the breast cancers detected in this study were visible by MRI only and these tumors were smaller and significantly more often node-negative than other screen-detected tumors, suggesting that MRI makes an important contribution to the early detection of hereditary breast cancer. |
| وصف الملف: | application/pdf |
| تدمد: | 1573-7217 0167-6806 |
| DOI: | 10.1007/s10549-006-9341-6 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfd783fc8191dfdcdc6e57c135bc50f5 https://doi.org/10.1007/s10549-006-9341-6 |
| Rights: | RESTRICTED |
| رقم الانضمام: | edsair.doi.dedup.....bfd783fc8191dfdcdc6e57c135bc50f5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15737217 01676806 |
|---|---|
| DOI: | 10.1007/s10549-006-9341-6 |