Determination and confirmation of selective estrogen receptor modulators (SERMs), anti-estrogens and aromatase inhibitors in bovine and porcine urine using UHPLC-MS/MS
| العنوان: | Determination and confirmation of selective estrogen receptor modulators (SERMs), anti-estrogens and aromatase inhibitors in bovine and porcine urine using UHPLC-MS/MS |
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| المؤلفون: | Georgios Kaklamanos, Leendert A. van Ginkel, Saskia S. Sterk, Thijs Meijer, Martien L. Essers |
| المصدر: | Food Additives & Contaminants. Pt. A, Chemistry, Analysis, Control, Exposure & Risk Assessment 34 (2017) 4 Food Additives & Contaminants. Pt. A, Chemistry, Analysis, Control, Exposure & Risk Assessment, 34(4), 641-651 |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Monsteradministratie & Coördinatie, Swine, Health, Toxicology and Mutagenesis, Anti estrogen, Endogeny, Urine, Pharmacology, Toxicology, 01 natural sciences, Formestane, BU Veterinary Drugs, Limit of Detection, Tandem Mass Spectrometry, Aromatase, Animal Husbandry, Chromatography, High Pressure Liquid, biology, Chemistry, Aromatase Inhibitors, anti-estrogens, 04 agricultural and veterinary sciences, General Medicine, 040401 food science, Substance Abuse Detection, Selective estrogen receptor modulator, aromatase inhibiters, SERMs, medicine.drug, Selective Estrogen Receptor Modulators, medicine.medical_specialty, bovine urine, formestane, medicine.drug_class, Uhplc ms ms, BU Dierbehandelingsmiddelen, 0404 agricultural biotechnology, Internal medicine, medicine, Animals, Aromatase inhibitor, 010401 analytical chemistry, Public Health, Environmental and Occupational Health, Androstenedione, Reproducibility of Results, General Chemistry, 0104 chemical sciences, Endocrinology, UHPLC-MS/MS, porcine urine, biology.protein, Drug and Narcotic Control, Cattle, Food Science |
| الوصف: | Selective estrogen receptor modulators (SERMs), anti-estrogens and aromatase inhibitors are prohibited in human sports doping. However, they also present a risk of being used illegally in animal husbandry for fattening purposes. A method was developed and validated using UHPLC-MS/MS for the determination and confirmation of SERMs, anti-estrogens and aromatase inhibiters in bovine and porcine urine. This method was used in a survey of more than 200 bovine and porcine urine samples from Dutch farms. In 18 out of 103 porcine urine samples (17%) and two out of 114 bovine samples (2%) formestane, an aromatase inhibitor, was detected. None of the other compounds was detected. From human doping control it is known that formestane can, in some cases, be of natural origin. Analyses of reference samples from untreated bovine and porcine animals demonstrated the presence of formestane in bovine animals, but not yet in porcine animals. Future research will focus on whether the detected formestane in porcine and bovine urine is from endogenous or exogenous origin, using GC-c-IRMS. |
| وصف الملف: | application/pdf; application/octet-stream |
| تدمد: | 1944-0057 1944-0049 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf23e838fc43aea3051804a977b71a6c https://pubmed.ncbi.nlm.nih.gov/28140792 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....bf23e838fc43aea3051804a977b71a6c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19440057 19440049 |
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