Growth and weight gain in children with juvenile idiopathic arthritis: results from the ReACCh-Out cohort
| العنوان: | Growth and weight gain in children with juvenile idiopathic arthritis: results from the ReACCh-Out cohort |
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| المؤلفون: | Paul Dancey, Rosie Scuccimarri, Stuart E. Turvey, Leanne M Ward, Alessandra Bruns, Earl D. Silverman, Roberta A. Berard, Ciarán M. Duffy, Rae S. M. Yeung, Deborah M. Levy, Suzanne E. Ramsey, Rayfel Schneider, Elie Haddad, Maggie Larché, Kimberly Morishita, Ronald M. Laxer, Johannes Roth, Jean Dorval, Claire LeBlanc, Heinrike Schmeling, Jaime Guzman, Roxana Bolaria, Nicole Johnson, Kiem Oen, Sarah Campillo, Brian M. Feldman, Lynn Spiegel, Susanne M. Benseler, Adam M. Huber, Katherine Gross, Paivi Miettunen, Gilles Boire, Gaëlle Chédeville, Elizabeth Stringer, Tristan Kerr, Roman Jurencak, David A. Cabral, Karen Watanabe Duffy, Kristin Houghton, Anne-Laure Chetaille, Bianca Lang, Janet Ellsworth, Shirley M. L. Tse, Natalie J. Shiff, Bonnie Cameron, Ross E. Petty, Michele Gibbon, Lori B. Tucker, Debbie Ehrmann Feldman, Alan M. Rosenberg, Claire St. Cyr, Jinhui Ma |
| المصدر: | Pediatric Rheumatology Online Journal Paediatrics Publications |
| بيانات النشر: | BioMed Central, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Male, Pediatrics, Juvenile, Arthritis, Growth, Weight Gain, 0302 clinical medicine, Prevalence, Immunology and Allergy, Medicine, Cumulative incidence, 030212 general & internal medicine, Prospective Studies, Prospective cohort study, Child, Growth Disorders, 2. Zero hunger, education.field_of_study, Anthropometry, Incidence, Child, Preschool, Cohort, Female, medicine.symptom, Research Article, medicine.medical_specialty, Canada, Adolescent, Population, Juvenile arthritis, Short stature, 03 medical and health sciences, Rheumatology, Corticosteroids, Humans, Obesity, Preschool, education, Glucocorticoids, 030203 arthritis & rheumatology, business.industry, Tall Stature, medicine.disease, Arthritis, Juvenile, Pediatrics, Perinatology and Child Health, Physical therapy, business, Body mass index, Weight gain, Follow-Up Studies |
| الوصف: | Background With modern treatments, the effect of juvenile idiopathic arthritis (JIA) on growth may be less than previously reported. Our objective was to describe height, weight and body mass index (BMI) development in a contemporary JIA inception cohort. Methods Canadian children newly-diagnosed with JIA 2005–2010 had weight and height measurements every 6 months for 2 years, then yearly up to 5 years. These measurements were used to calculate mean age- and sex-standardized Z-scores, and estimate prevalence and cumulative incidence of growth impairments, and the impact of disease activity and corticosteroids on growth. Results One thousand one hundred forty seven children were followed for median 35.5 months. Mean Z-scores, and the point prevalence of short stature (height 95th percentile, 15.8% to 16.4%) remained unchanged in the whole cohort. Thirty-three children (2.9%) developed new-onset short stature, while 27 (2.4%) developed tall stature (>97.5th percentile). Children with systemic arthritis (n = 77) had an estimated 3-year cumulative incidence of 9.3% (95%CI: 4.3–19.7) for new-onset short stature and 34.4% (23–49.4) for obesity. Most children (81.7%) received no systemic corticosteroids, but 1 mg/Kg/day prednisone-equivalent maintained for 6 months corresponded to a drop of 0.64 height Z-scores (0.56–0.82) and an increase of 0.74 BMI Z-scores (0.56–0.92). An increase of 1 in the 10-cm physician global assessment of disease activity maintained for 6 months corresponded to a drop of 0.01 height Z-scores (0–0.02). Conclusions Most children in this modern JIA cohort grew and gained weight as children in the general population. About 1 in 10 children who had systemic arthritis, uncontrolled disease and/or prolonged corticosteroid use, had increased risk of growth impairment. Electronic supplementary material The online version of this article (doi:10.1186/s12969-017-0196-7) contains supplementary material, which is available to authorized users. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1546-0096 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::beb972931a5be0a795d241313b5087da http://europepmc.org/articles/PMC5567720 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....beb972931a5be0a795d241313b5087da |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15460096 |
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