Enantioselective Synthesis of Spiroindolines via Cascade Isomerization/Spirocyclization/Dearomatization Reaction
| العنوان: | Enantioselective Synthesis of Spiroindolines via Cascade Isomerization/Spirocyclization/Dearomatization Reaction |
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| المؤلفون: | Wenbin Shang, Xu Ji, Yuchang Liu, Chengfeng Xia, Zhiqiang Pan, Qinglong Liu, Fengchi Hu |
| المصدر: | Organic Letters. 22:1589-1593 |
| بيانات النشر: | American Chemical Society (ACS), 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Indole test, 010405 organic chemistry, Monoterpene, Organic Chemistry, Enantioselective synthesis, 010402 general chemistry, 01 natural sciences, Biochemistry, Combinatorial chemistry, 0104 chemical sciences, Catalysis, Enamine, chemistry.chemical_compound, Cascade reaction, chemistry, Physical and Theoretical Chemistry, Nonane, Isomerization |
| الوصف: | The spiroindoline skeleton featured with 2,7-diazaspiro[4.4]nonane exists in various structurally intricate and biologically active monoterpene indole alkaloids. A catalytic asymmetric cascade enamine isomerization/spirocyclization/dearomatization succession to construct the spiroindoline was developed, which employed the indolyl dihydropyridine as a substrate under catalysis of the chiral phosphoric acid. This cascade reaction provided various spiroindolines in both diastereoselective and enantionselective fashions. |
| تدمد: | 1523-7052 1523-7060 |
| DOI: | 10.1021/acs.orglett.0c00181 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be9623cb2073c63d12da49794becb4ae https://doi.org/10.1021/acs.orglett.0c00181 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....be9623cb2073c63d12da49794becb4ae |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15237052 15237060 |
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| DOI: | 10.1021/acs.orglett.0c00181 |