Curative intent Stereotactic Ablative Radiation Therapy (SABR) for treatment of lung oligometastases from head and neck squamous cell carcinoma (HNSCC): a multi-institutional retrospective study
| العنوان: | Curative intent Stereotactic Ablative Radiation Therapy (SABR) for treatment of lung oligometastases from head and neck squamous cell carcinoma (HNSCC): a multi-institutional retrospective study |
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| المؤلفون: | Kamel, Debbi, Gokoulakrichenane, Loganadane, Nhu Hanh, To, Remy, Kinj, Zain A, Husain, Sophie, Chapet, Nam P, Nguyen, Isabelle, Barillot, Karen, Benezery, Yazid, Belkacemi, Gilles, Calais |
| المصدر: | The British Journal of Radiology. 95 |
| بيانات النشر: | British Institute of Radiology, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Lung Neoplasms, Treatment Outcome, Head and Neck Neoplasms, Squamous Cell Carcinoma of Head and Neck, Humans, Radiology, Nuclear Medicine and imaging, General Medicine, Radiosurgery, Lung, Aged, Retrospective Studies |
| الوصف: | Objectives: The aim of this retrospective study was to assess outcomes of SABR for metachronous isolated lung oligometastases from HNSCC. Methods: For patients who developed isolated, 1 or 2 lungs lesions (Results: Between November 2007 and February 2018, 52 patients were treated with SABR for metachronous lung metastases. The median time from the treatment of the primary HNSCC to the development of lung metastases was 18 months (3-93). The cohort’s median age was 65.5 years old (50-83). The vast majority (94.2%) received 60 Gy in three fractions. Forty-one patients (78.5%) presented a solitary lung metastasis, while 11 patients (21.5%) had two lung metastases. With a median follow-up of 45.3 months, crude local and metastatic control rates were 74 and 38%, respectively. 1 year and 2 year Overall Survival (OS) were 85.8 and 65.9%, respectively. The median OS was 46.8 months. About one-fourth of patients were retreated by SABR for distant pulmonary recurrence. The treatment was well tolerated with only one patient who reported ≥ grade 3 toxicity (1.9%). Conclusion: In selected metastatic HNSCC patients, early detection and treatment of lung metastases with SABR is effective and safe. Prospective studies are required to validate this potential shift. Advances in knowledge: Patients with oligometastases and controlled primary HNSCC seem to benefit from metastasis directed therapies. |
| تدمد: | 1748-880X 0007-1285 |
| DOI: | 10.1259/bjr.20210033 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bde0266f24d43c0ddd00a1cd275a3ffd https://doi.org/10.1259/bjr.20210033 |
| رقم الانضمام: | edsair.doi.dedup.....bde0266f24d43c0ddd00a1cd275a3ffd |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1748880X 00071285 |
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| DOI: | 10.1259/bjr.20210033 |