Maternal schistosomiasis: IL-2, IL-10 and regulatory T lymphocytes to unrelated antigen in adult offspring mice
| العنوان: | Maternal schistosomiasis: IL-2, IL-10 and regulatory T lymphocytes to unrelated antigen in adult offspring mice |
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| المؤلفون: | Erica de Souza Fernandes, Yara M. Gomes, Virgínia Maria de Barros Lorena, Vlaudia Maria Assis Costa, Iana Rafaela Fernandes Sales, Mônica Camelo Pessoa de Azevedo Albuquerque, Valdênia Maria Oliveira Souza |
| المصدر: | Revista da Sociedade Brasileira de Medicina Tropical, Volume: 51, Issue: 4, Pages: 546-549, Published: AUG 2018 Revista da Sociedade Brasileira de Medicina Tropical, Vol 51, Iss 4, Pp 546-549 |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | 0301 basic medicine, Microbiology (medical), lcsh:Arctic medicine. Tropical medicine, lcsh:RC955-962, Offspring, Ovalbumin, Antibodies, Helminth, chemical and pharmacologic phenomena, Spleen, T-Lymphocytes, Regulatory, Immunomodulation, 03 medical and health sciences, Mice, Antigen, Immunity, Pregnancy, medicine, Animals, biology, business.industry, Adult offspring, hemic and immune systems, Flow Cytometry, Schistosomiasis mansoni, Animals, Suckling, Interleukin-10, Interleukin 10, 030104 developmental biology, Infectious Diseases, medicine.anatomical_structure, Immunization, Immunology, biology.protein, Interleukin-2, Parasitology, Female, Antibody, business, Maternal schistosomiasis |
| الوصف: | INTRODUCTION: We evaluated IL-10, IL-2 and regulatory T cells (Treg), in response to ovalbumin (OA), in offspring from schistosomotic mouse mothers. METHODS: We used animals born (BIM) or suckled (SIM) from infected mothers; and mice born/suckled from infected (BSIM) or non-infected mothers (CONTROL). After OA+adjuvant immunization, spleen cells were cultured, with or without OA, and doubly marked for cytometry. RESULTS: BIM showed fewer CD4+/IL-2+ and more B220+/IL-10+ cells, whereas the SIM group showed increased Treg frequency. BSIM had fewer B220+/IL-10+ and Treg cells. CONCLUSIONS: Separately, gestation or nursing induced immunosuppressive cells in infected mothers, but improved anti-OA immunity when combined. |
| وصف الملف: | text/html |
| تدمد: | 1678-9849 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd5093bf75b49632f9c647e542537e4d https://pubmed.ncbi.nlm.nih.gov/30133643 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....bd5093bf75b49632f9c647e542537e4d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16789849 |
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