Exploring the genetics underpinning dynamic laryngeal collapse associated with poll flexion in Norwegian‐Swedish Coldblooded Trotter racehorses
| العنوان: | Exploring the genetics underpinning dynamic laryngeal collapse associated with poll flexion in Norwegian‐Swedish Coldblooded Trotter racehorses |
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| المؤلفون: | Cathrine T. Fjordbakk, Maria K. Rosengren, K. Jäderkvist Fegraeus, P. M. Smith, C. F. Ihler, Marina Solé, Eric Strand, Brandon D. Velie, Gabriella Lindgren, Knut Røed |
| المصدر: | Equine Veterinary Journal. 52:174-180 |
| بيانات النشر: | Wiley, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | medicine.medical_specialty, DISORDERS, 040301 veterinary sciences, Genomic data, HARNESS RACEHORSES, Single-nucleotide polymorphism, Norwegian, HORSES, genomic, 0403 veterinary science, Internal medicine, PROTEIN FAMILIES, PANTHER, medicine, Animals, Veterinary Sciences, Horses, Prospective Studies, Genotyping, Sweden, Science & Technology, harness racing, MUTATIONS, Norway, business.industry, Haplotype, 0402 animal and dairy science, Small sample, 04 agricultural and veterinary sciences, General Medicine, 040201 dairy & animal science, language.human_language, horse, upper respiratory tract disorder, Increased risk, LINKAGE PHASE, TESTS, language, Horse Diseases, Larynx, business, Life Sciences & Biomedicine, performance, Genome-Wide Association Study |
| الوصف: | BACKGROUND: Dynamic laryngeal collapse (DLC) associated with poll flexion is the most common disorder of the upper respiratory tract (URT) in the Norwegian-Swedish Coldblooded Trotter (NSCT). The disorder, which has also been diagnosed in other breeds of trotters and gaited horses, appears to be related to anatomic phenotypes and only occurs during poll flexion when the horse is exercised 'on the bit'. OBJECTIVES: Identify genomic regions associated with DLC in the NSCT by combining a rigorous phenotyping protocol with genomic data from a high-density equine genotyping array. STUDY DESIGN: Prospective case/control study. METHODS: High-speed treadmill endoscopy was used to phenotype horses (n = 61) for DLC, distinguishing between cases and controls. Genome-wide association (GWA) analysis of DLC status was then performed using a principal component approach (PCA) with haplotype analyses subsequently performed for regions containing single-nucleotide polymorphisms (SNPs) above the suggestive genome-wide significance (GWS) threshold (P |
| وصف الملف: | Print-Electronic |
| تدمد: | 2042-3306 0425-1644 |
| DOI: | 10.1111/evj.13171 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd1f25fa1ea0f46d718e5da99852d885 https://doi.org/10.1111/evj.13171 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....bd1f25fa1ea0f46d718e5da99852d885 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20423306 04251644 |
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| DOI: | 10.1111/evj.13171 |