Genetic variations in the homologous recombination repair pathway genes modify risk of glioma
| العنوان: | Genetic variations in the homologous recombination repair pathway genes modify risk of glioma |
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| المؤلفون: | Liangfu Zhou, Yanhong Liu, Chunxia Cheng, Haishi Zhang, Renke Zhou, Keke Zhou, Chengcheng Zhou, Qingyi Wei, Daru Lu |
| المصدر: | Journal of Neuro-Oncology. 126:11-17 |
| بيانات النشر: | Springer Science and Business Media LLC, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Adult, Male, 0301 basic medicine, Cancer Research, Adolescent, Genotype, Single-nucleotide polymorphism, Ataxia Telangiectasia Mutated Proteins, Biology, Polymorphism, Single Nucleotide, Young Adult, 03 medical and health sciences, Asian People, Gene Frequency, Risk Factors, Glioma, medicine, Humans, Genetic Predisposition to Disease, Allele, Genotyping, Genetic Association Studies, Genetics, Multifactor dimensionality reduction, Brain Neoplasms, Recombinational DNA Repair, DNA Repair Pathway, Middle Aged, medicine.disease, Homologous Recombination Pathway, 030104 developmental biology, Neurology, Oncology, Case-Control Studies, Female, Neurology (clinical), Signal Transduction |
| الوصف: | Accumulative epidemiological evidence suggests that single nucleotide polymorphisms (SNPs) in genes involved in homologous recombination (HR) DNA repair pathway play an important role in glioma susceptibility. However, the effects of such SNPs on glioma risk remain unclear. We used a used a candidate pathway-based approach to elucidate the relationship between glioma risk and 12 putative functional SNPs in genes involved in the HR pathway. Genotyping was conducted on 771 histologically-confirmed glioma patients and 752 cancer-free controls from the Chinese Han population. Odds ratios (OR) were calculated both for each SNP individually and for grouped analyses, examining the effects of the numbers of adverse alleles on glioma risk, and evaluated their potential gene-gene interactions using the multifactor dimensionality reduction (MDR). In the single-locus analysis, two variants, the NBS1 rs1805794 (OR 1.42, 95% CI 1.15-1.76, P = 0.001), and RAD54L rs1048771 (OR 1.61, 95% CI 1.17-2.22, P = 0.002) were significantly associated with glioma risk. When we examined the joint effects of the risk-conferring alleles of these three SNPs, we found a significant trend indicating that the risk increases as the number of adverse alleles increase (P = 0.005). Moreover, the MDR analysis suggested a significant three-locus interaction model involving NBS1 rs1805794, MRE11 rs10831234, and ATM rs227062. These results suggested that these variants of the genes involved in the HR pathway may contribute to glioma susceptibility. |
| تدمد: | 1573-7373 0167-594X |
| DOI: | 10.1007/s11060-015-1892-0 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd15c5d22c6c1ddb1d24030ab3270c3f https://doi.org/10.1007/s11060-015-1892-0 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....bd15c5d22c6c1ddb1d24030ab3270c3f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15737373 0167594X |
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| DOI: | 10.1007/s11060-015-1892-0 |