Left and right ventricular functions may be impaired in children diagnosed with subclinical hypothyroidism
| العنوان: | Left and right ventricular functions may be impaired in children diagnosed with subclinical hypothyroidism |
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| المؤلفون: | Alper Akın, Mehmet Türe, Ruken Yıldırım, Edip Unal, Hasan Balık, Yusuf Kenan Haspolat |
| المساهمون: | Dicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı, Akın, Alper, Ünal, Edip, Yıldırım, Ruken, Türe, Mehmet, Balık, Hasan, Haspolat, Yusuf Kenan |
| المصدر: | Scientific Reports Scientific Reports, Vol 10, Iss 1, Pp 1-8 (2020) |
| بيانات النشر: | Nature Publishing Group UK, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Male, Performance, Ventricular Dysfunction, Right, Doppler-echocardiograhy, lcsh:Medicine, Cardiac-function, 030204 cardiovascular system & hematology, Adolescents, Doppler imaging, Ventricular Dysfunction, Left, 0302 clinical medicine, Disease, Myocardial Performance Index, Patient group, lcsh:Science, Child, L-Thyroxine therapy, Subclinical infection, Multidisciplinary, Ventricular function, Echocardiography, Doppler, Child, Preschool, Cardiology, cardiovascular system, Female, Thyroid-hormone, Risk, Cardiac function curve, medicine.medical_specialty, congenital, hereditary, and neonatal diseases and abnormalities, Adolescent, Diastole, 030209 endocrinology & metabolism, Article, 03 medical and health sciences, Diastolic-function, Hypothyroidism, Internal medicine, medicine, Humans, cardiovascular diseases, Normal range, business.industry, lcsh:R, Cardiovascular biology, Thyroid diseases, Thyroxine, Dysfunction, Case-Control Studies, lcsh:Q, business |
| الوصف: | Subclinical hypothyroidism (SH) may influence both ventricular functions. The aim of this study was to evaluation the findings of Tissue Doppler Imaging (TDI) and other echocardiography modalities in children with SH. We compared left ventricular mass index (LVMI) and TDI parameters of patients with SH and children with euthyroidism. Subclinical hypothyroidism was diagnosed when thyroid stimulating hormone level was higher than the reference value of the laboratory (> 4.2 mIU/L) and free thyroxine level was in normal range. The study included a group of 35 patients with SH and a control group of 38 children with euthyroidism (mean age was 7.6 ± 3.5 years and 9.0 ± 2.4 years, respectively). LVMI was significantly higher in the patient group (p = 0.005). TDI parameters including mitral septal ejection time was lower (p = 0.003) and mitral septal myocardial performance index was higher (p = 0.009) in the patient group. Right ventricular TDI revealed that tricuspid lateral E/Ea and tricuspid septal E/Ea were higher (p = 0.015 and p = 0.024, respectively) and tricuspid septal Ea/Aa and ejection time were lower (p = 0.018 and p = 0.017, respectively) in the patient group. SH may lead to increase LVMI. Left ventricular systolic and diastolic TDI parameters (lower mitral septal ejection time, higher mitral septal myocardial performance index) as well as right ventricular systolic (lower tricuspid septal ejection time) and diastolic (higher tricuspid septal and lateral E/Ea, lower tricuspid septal Ea/Ea) functions may be also impaired in children with subclinical hypothyroidism. TDI is a useful method used for the assessment of the effect of SH on cardiac functions. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2045-2322 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc98e2dd35f6d28b5b5264f1c693ca69 http://europepmc.org/articles/PMC7661521 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....bc98e2dd35f6d28b5b5264f1c693ca69 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20452322 |
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