Early Variations in White Matter Microstructure and Depression Outcome in Adolescents With Subthreshold Depression
| العنوان: | Early Variations in White Matter Microstructure and Depression Outcome in Adolescents With Subthreshold Depression |
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| المؤلفون: | Sylvane Desrivières, Arun L.W. Bokde, Jean-Luc Martinot, Jani Penttilä, Betteke van Noort, Dimitri Papadopoulos-Orfanos, Luise Poustka, Hélène Vulser, Viola Kappel, Tomáš Paus, Gareth J. Barker, Yvonne Grimmer, Robert Goodman, Gunter Schumann, Marie-Laure Paillère Martinot, Robert Whelan, Uli Bromberg, Michael N. Smolka, Vincent Frouin, Charbel Massaad, Tahmine Fadai, Penny A. Gowland, Frauke Nees, Ruben Miranda, Juergen Gallinat, Argyris Stringaris, Christian Büchel, Henrik Walter, Andreas Heinz, Herve Lemaitre, Herta Flor, Eleni T. Tzavara, Anna Cattrell, Sarah Rodehacke, Eric Artiges, Patricia J. Conrod, Maren Struve, Tobias Banaschewski, Hugh Garavan, Rüdiger Brühl |
| المصدر: | 2018, ' Early variations in white matter microstructure and depression outcome in adolescents with subthreshold depression ', American Journal of Psychiatry, vol. 175, no. 12, pp. 1255-1264 . https://doi.org/10.1176/appi.ajp.2018.17070825 |
| بيانات النشر: | American Psychiatric Association Publishing, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Adolescent, Prodromal Symptoms, Uncinate fasciculus, Neuroimaging, Audiology, Corpus callosum, Corpus Callosum, White matter, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Surveys and Questionnaires, Fractional anisotropy, medicine, Humans, Cingulum (brain), Longitudinal Studies, Anterior cingulate cortex, Psychiatric Status Rating Scales, Depression, business.industry, Brain, White Matter, 030227 psychiatry, Psychiatry and Mental health, Diffusion Magnetic Resonance Imaging, Diffusion Tensor Imaging, medicine.anatomical_structure, Case-Control Studies, Female, business, 030217 neurology & neurosurgery, Diffusion MRI, Tractography |
| الوصف: | Objective: White matter microstructure alterations have recently been associated with depressive episodes during adolescence, but it is unknown whether they predate depression. The authors investigated whether subthreshold depression in adolescence is associated with white matter microstructure variations and whether they relate to depression outcome. Method: Adolescents with subthreshold depression (N=96) and healthy control subjects (N=336) drawn from a community-based cohort were compared using diffusion tensor imaging and whole brain tract-based spatial statistics (TBSS) at age 14 to assess white matter microstructure. They were followed up at age 16 to assess depression. Probabilistic tractography was used to reconstruct white matter streamlines spreading from the regions identified in the TBSS analysis and along bundles implicated in emotion regulation, the uncinate fasciculus and the cingulum. The authors searched for mediating effects of white matter microstructure on the relationship between baseline subthreshold depression and depression at follow-up, and then explored the specificity of the findings. Results: Lower fractional anisotropy (FA) and higher radial diffusivity were found in the anterior corpus callosum in the adolescents with subthreshold depression. Tractography analysis showed that they also had lower FA in the right cingulum streamlines, along with lower FA and higher mean diffusivity in tracts connecting the corpus callosum to the anterior cingulate cortex. The relation between subthreshold depression at baseline and depression at follow-up was mediated by FA values in the latter tracts, and lower FA values in those tracts distinctively predicted higher individual risk for depression. Conclusions: Early FA variations in tracts projecting from the corpus callosum to the anterior cingulate cortex may denote a higher risk of transition to depression in adolescents. |
| وصف الملف: | application/pdf |
| تدمد: | 1535-7228 0002-953X |
| DOI: | 10.1176/appi.ajp.2018.17070825 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbede111b3b19fa648b50b84003fb07c https://doi.org/10.1176/appi.ajp.2018.17070825 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....bbede111b3b19fa648b50b84003fb07c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15357228 0002953X |
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| DOI: | 10.1176/appi.ajp.2018.17070825 |