Refill liquids for electronic cigarettes display peculiar toxicity on human endothelial cells
| العنوان: | Refill liquids for electronic cigarettes display peculiar toxicity on human endothelial cells |
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| المؤلفون: | Sara De Martin, Daniela Gabbia, Franco Biasioli, Sara Bogialli, Daniela Rainer, Ronald Gstir, Luca Cappellin, Andrea Boschetti |
| المصدر: | Toxicology Reports Toxicology Reports, Vol 8, Iss, Pp 456-462 (2021) |
| بيانات النشر: | Elsevier, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Health, Toxicology and Mutagenesis, Cytotoxicity, 010501 environmental sciences, Pharmacology, Lung injury, Toxicology, 01 natural sciences, Nicotine, 03 medical and health sciences, 0302 clinical medicine, RA1190-1270, Refill liquids, medicine, EVALI, e-vaping acute lung injury, HUVEC, human umbilical vein endothelial cells, Settore VET/07 - FARMACOLOGIA E TOSSICOLOGIA VETERINARIA, 0105 earth and related environmental sciences, ComputingMethodologies_COMPUTERGRAPHICS, e-Cig, electronic cigarette, LDH - Lactate dehydrogenase, LDH, lactate dehydrogenase, Chemistry, EVALI, Regular Article, ENDS, electronic nicotine delivery systems, Ldh release, Electronic cigarettes, Toxicity, Toxicology. Poisons, 030217 neurology & neurosurgery, medicine.drug |
| الوصف: | Graphical abstract Highlights • The vapors obtained from different refill liquids for e-cigarettes exert different extent of cytotoxicity. • The condensates obtained from traditional cigarettes are always highly cytotoxic in the same experimental conditions. • Accurate evaluations for refill liquids will help to correlate toxicity to chemical composition. The electronic cigarettes mimic combustible cigarettes through a heating technology that vaporizes a refill liquid consisting of solvents, flavors, and nicotine. E-cigarettes are sometimes still used as a support for smoking cessation, even if in 2019 an acute lung injury outbreak occurred in the USA, affecting mainly adolescents and young adults, and was correlated to eCigs. Therefore, due to the lack of a definite knowledge about the mechanism(s) of refill liquid toxicity and considering that previous investigations gave controversial results, the aim of the present study was the cytotoxicity assessment of different refill liquids on human endothelial cells, evaluated by means of two different in vitro approaches, i.e. the resazurin and the LDH release assays. Our results clearly demonstrated that different refill liquids (6 samples) display different levels of cytotoxicity in our cellular model, although their cytotoxicity was always lower than that observed for the condensate obtained from traditional cigarettes (3 samples). These results suggest that accurate evaluations should be provided for refill liquids, in particular to correlate their toxicity to their chemical composition, with the final aim of obtaining useful information for the agencies involved in the regulation of their components. |
| اللغة: | English |
| تدمد: | 2214-7500 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbddc929f4c1ea0d46cf52ba9a1190ea http://europepmc.org/articles/PMC7933715 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....bbddc929f4c1ea0d46cf52ba9a1190ea |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22147500 |
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