Isolation, Absolute Configuration and Cytotoxic Activities of Alkaloids from Hippeastrum goianum (Ravenna) Meerow (Amaryllidaceae)
| العنوان: | Isolation, Absolute Configuration and Cytotoxic Activities of Alkaloids from Hippeastrum goianum (Ravenna) Meerow (Amaryllidaceae) |
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| المؤلفون: | Andrea N. L. Batista, Letícia V. Costa-Lotufo, Mariacaterina Lianza, Warley de Souza Borges, Jaume Bastida, Maria Helena Verdan, Álvaro Cunha Neto, João M. Batista, Sarah Christina Caldas Oliveira, Larissa Costa de Almeida, Jean Paulo de Andrade, Ferruccio Poli |
| المساهمون: | Mariacaterina Lianza, Maria Helena Verdan, Jean Paulo de Andrade, Ferruccio Poli, Larissa de Almeida, Leticia Costa-Lotufo, Álvaro Cunha Neto, Sarah Oliveira, Jaume Bastida, Andrea Batista, João Batista Jr., Warley Borges |
| المصدر: | Dipòsit Digital de la UB Universidad de Barcelona Journal of the Brazilian Chemical Society, Volume: 31, Issue: 10, Pages: 2135-2145, Published: 09 OCT 2020 Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP Journal of the Brazilian Chemical Society v.31 n.10 2020 Journal of the Brazilian Chemical Society Sociedade Brasileira de Química (SBQ) instacron:SBQ |
| بيانات النشر: | Sociedade Brasileira de Quimica (SBQ), 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Stereochemistry, Circular dichroism, FARMACOLOGIA, Cell-mediated cytotoxicity, narciclasine, galasine, cytotoxic activity, absolute configuration, vibrational, circular dichroism, Alkaloids, Hippeastrum, Alcaloides, Dicroisme circular, Cytotoxicity, IC50, cytotoxic activity, Tumors, biology, Chemistry, Absolute configuration, General Chemistry, Amaryllidaceae, vibrational circular dichroism, biology.organism_classification, Citotoxicitat per mediació cel·lular, absolute configuration, Phytochemical, Cell culture, Vibrational circular dichroism, galasine, narciclasine |
| الوصف: | The phytochemical study of Hippeastrum goianum led to the identification of 13 compounds by means of gas chromatography-mass spectrometry (GC-MS) and nuclear magnetic resonance (NMR). Compounds 7-demethoxy-9-O-methylhostasine (1) and 7-deoxi-trans-dihydronarciclasine (2) had their absolute configurations determined by vibrational circular dichroism (VCD). This is the first time that compound 1 is described in the Amaryllidaceae family. The cytotoxicity of all isolated compounds was tested against colorectal carcinoma (HCT 116), breast carcinoma (MCF-7), and non-tumor human retinal pigment epithelium (RPE) cell lines. The half-maximum inhibitory concentration (IC50) of compound 2 against each cell line was equivalent to the positive control (doxorubicin), indicating a considerable cytotoxic activity. Keywords: narciclasine; galasine; cytotoxic activity; absolute configuration; vibrational circular dichroism |
| وصف الملف: | application/pdf; text/html; STAMPA |
| تدمد: | 0103-5053 |
| DOI: | 10.21577/0103-5053.20200116 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb756092c41a144efe2218f663cd8c01 https://doi.org/10.21577/0103-5053.20200116 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....bb756092c41a144efe2218f663cd8c01 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 01035053 |
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| DOI: | 10.21577/0103-5053.20200116 |