LncRNA AK131850 is downregulated in thoracic aortic aneurysm and negatively affects the levels of TGF-β1 in aortic smooth muscle cells
| العنوان: | LncRNA AK131850 is downregulated in thoracic aortic aneurysm and negatively affects the levels of TGF-β1 in aortic smooth muscle cells |
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| المؤلفون: | Bing Liu, Shengjie Fu, Han Wang, Yongqi Li, Lei Li, Xiulei Cai, Yu Tian |
| المصدر: | Archives of Physiology and Biochemistry. 128:1302-1307 |
| بيانات النشر: | Informa UK Limited, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Aortic Aneurysm, Thoracic, Physiology, business.industry, Myocytes, Smooth Muscle, 030209 endocrinology & metabolism, General Medicine, medicine.disease, Thoracic aortic aneurysm, Transforming Growth Factor beta1, 03 medical and health sciences, 0302 clinical medicine, Downregulation and upregulation, Smooth muscle, 030220 oncology & carcinogenesis, Physiology (medical), cardiovascular system, Cancer research, medicine, Humans, RNA, Long Noncoding, RNA, Small Interfering, Sirna silencing, business, Transforming growth factor |
| الوصف: | This study aimed to investigate the role of lncRNA AK131850 in thoracic aortic aneurysm (TAA). We found that AK131850 was downregulated, while TGF-β1 was upregulated in aortic media specimen of thoracic aortic aneurysm (TAA) patients. In addition, AK131850 and TGF-β1 inversely correlated. Altered expression levels of AK131850 and TGF-β1 distinguished TAA patients from healthy controls. In human aortic smooth muscle cells (HAOSMC), AK131850 overexpression led to downregulated, while AK131850 siRNA silencing led to upregulated TGF-β1. AK131850 overexpression resulted in promoted, while siRNA silencing led to inhibited proliferation of HAOSMC. Therefore, AK131850 is downregulated in thoracic aortic aneurysm and negatively affects the levels of TGF-β1 in aortic smooth muscle cells. |
| تدمد: | 1744-4160 1381-3455 |
| DOI: | 10.1080/13813455.2020.1767653 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb71b591419af38055134bcd836d9a49 https://doi.org/10.1080/13813455.2020.1767653 |
| رقم الانضمام: | edsair.doi.dedup.....bb71b591419af38055134bcd836d9a49 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17444160 13813455 |
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| DOI: | 10.1080/13813455.2020.1767653 |