Antibiotic-Loaded Hydrogel Coating to Reduce Early Postsurgical Infections in Aseptic Hip Revision Surgery: A Retrospective, Matched Case-Control Study
| العنوان: | Antibiotic-Loaded Hydrogel Coating to Reduce Early Postsurgical Infections in Aseptic Hip Revision Surgery: A Retrospective, Matched Case-Control Study |
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| المؤلفون: | Pietro Persiani, Ciro Villani, Armando Ugo Cavallo, Lorenzo Are, Daniele De Meo, Valeria Calogero |
| المصدر: | Microorganisms Volume 8 Issue 4 Microorganisms, Vol 8, Iss 571, p 571 (2020) |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Microbiology (medical), local antibiotics, medicine.medical_specialty, Periprosthetic, antibacterial coating, Microbiology, Osseointegration, Article, biofilm, 03 medical and health sciences, 0302 clinical medicine, Virology, medicine, 030212 general & internal medicine, Antibiotic prophylaxis, Adverse effect, lcsh:QH301-705.5, Hip surgery, 030222 orthopedics, periprosthetic joint infection, business.industry, antibiotic prophylaxis, Case-control study, Implant failure, Retrospective cohort study, infection, Surgery, lcsh:Biology (General), hip revision, hydrogel, business |
| الوصف: | Periprosthetic joint infections (PJIs) are a cause of frequent implant failure in revision hip replacement surgery. The purpose of this study is to evaluate the onset of early postoperative infections in patients who underwent hip surgery with cementless prostheses treated with an antibiotic loaded hydrogel on their surface, in addition to systemic prophylaxis, and compare them to a control group. The secondary objective was to evaluate the onset of any local and systemic adverse effects and interference with bone ingrowth processes and functional recovery. A retrospective observational study was conducted on patients who underwent revision hip surgery by performing a 1:1 match between patients treated with an antibiotic hydrogel (ALH) and the control patients. The incidence of PJIs was assessed with a minimum of six months follow-up. Seventeen patients treated with the ALH were compared with 17 patients from the control group. No PJIs were reported in the ALH group versus the six cases encountered in the control group (p < 0.0001). No significant differences were reported with regard to prosthetic osseointegration and functional results, nor were there side effects in the ALH group. Despite the low sample size, the use of on-site prophylaxis with ALH has proven effective and safe in reducing the risk of PJIs in patients with a high risk for infections. Further studies are needed to validate these results in other implant-related surgeries. |
| وصف الملف: | application/pdf |
| تدمد: | 2076-2607 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb6a606c15e42d5ee103b210c8fc3b34 https://pubmed.ncbi.nlm.nih.gov/32326577 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....bb6a606c15e42d5ee103b210c8fc3b34 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20762607 |
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