Trilineage Phenotypic Compromise in Acute Leukemia
| العنوان: | Trilineage Phenotypic Compromise in Acute Leukemia |
|---|---|
| المؤلفون: | Federico R Ramírez, Maria M.E. de Bracco, M. V. Castuma, María Fernanda Palacios, Mariano Scolnik, R. Tur |
| المصدر: | Leukemia & Lymphoma. 34:395-399 |
| بيانات النشر: | Informa UK Limited, 1999. |
| سنة النشر: | 1999 |
| مصطلحات موضوعية: | Adult, Male, Cancer Research, medicine.medical_specialty, Acute leukemia, Myeloid, Acute Biphenotypic Leukemia, Cytogenetics, Cell Separation, Hematology, Biology, Flow Cytometry, Phenotype, Leukemia, Myeloid, Acute, Fatal Outcome, medicine.anatomical_structure, Immunophenotyping, Oncology, Antigen, hemic and lymphatic diseases, Immunology, medicine, Humans, Sudan black |
| الوصف: | The expression of three lineage specific antigens in the leukemic blasts is extremely infrequent. We here report a case of triphenotypic acute leukemia with involvement of the myeloid and B and T lineages. The morphology of the blasts showed promyelocytic features with agranular cytoplasm, suggesting a M3-variant of AML. The blasts were positive for myeloperoxidase PAS and Sudan Black. Immunophenotype and cytogenetics did not confirm M3-AML diagnosis, showing a trilineage compromise (myeloid and T and B lymphoid markers) and the cytogenetic alterations +8 and +11, respectively. This report highlights the importance of correlating the results of multiple diagnostic methods in order to establish a correct diagnosis of mixed lineage acute leukemias, and allows evaluation of the prognostic importance of this subgroup of patients. |
| تدمد: | 1029-2403 1042-8194 |
| DOI: | 10.3109/10428199909050965 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bacbb3b23586ea589ba8ffc9a0d3fb40 https://doi.org/10.3109/10428199909050965 |
| رقم الانضمام: | edsair.doi.dedup.....bacbb3b23586ea589ba8ffc9a0d3fb40 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10292403 10428194 |
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| DOI: | 10.3109/10428199909050965 |