Evaluation of chemical restraint, isoflurane anesthesia and methadone or tramadol as preventive analgesia in spotted pacas (Cuniculus paca) subjected to laparoscopy
| العنوان: | Evaluation of chemical restraint, isoflurane anesthesia and methadone or tramadol as preventive analgesia in spotted pacas (Cuniculus paca) subjected to laparoscopy |
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| المؤلفون: | Aline Eyko Kawanami, Ricardo R. A. Uscategui, Wilter Rr. Vicente, Vivian Tavares de Almeida, Marcus Ar. Feliciano, Felipe F F P C Barros |
| المساهمون: | Universidade Federal de Viçosa (UFV), Universidade Estadual Paulista (Unesp), Federal Rural University of Rio de Janeiro (UFRRJ), Universidade Federal de Sergipe (UFS) |
| المصدر: | Scopus Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | tramadol, ketamine, 040301 veterinary sciences, Anesthesia, General, Preventive analgesia, 0403 veterinary science, methadone, 03 medical and health sciences, isoflurane, 0302 clinical medicine, Chemical restraint, 030202 anesthesiology, Cuniculidae, Heart Rate, medicine, Animals, Ketamine, Prospective Studies, Tramadol, General Veterinary, Isoflurane, business.industry, 04 agricultural and veterinary sciences, midazolam, Anesthesia, rodents, Anesthetic, Anesthetics, Inhalation, Midazolam, Female, Laparoscopy, Analgesia, business, Methadone, medicine.drug |
| الوصف: | Made available in DSpace on 2021-06-25T11:08:06Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-01-01 Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Objective: To evaluate the efficacy and cardiopulmonary effects of ketamine–midazolam for chemical restraint, isoflurane anesthesia and tramadol or methadone as preventive analgesia in spotted pacas subjected to laparoscopy. Study design: Prospective placebo-controlled blinded trial. Animals: A total of eight captive female Cuniculus paca weighing 9.3 ± 0.9 kg. Methods: Animals were anesthetized on three occasions with 15 day intervals. Manually restrained animals were administered midazolam (0.5 mg kg–1) and ketamine (25 mg kg–1) intramuscularly. Anesthesia was induced and maintained with isoflurane 30 minutes later. Tramadol (5 mg kg–1), methadone (0.5 mg kg–1) or saline (0.05 mL kg–1) were administered intramuscularly 15 minutes prior to laparoscopy. Heart rate (HR), respiratory rate, mean arterial pressure (MAP), peripheral oxygen saturation (SpO2), end-tidal CO2 partial pressure (PE′CO2), end-tidal concentration of isoflurane (FE′Iso), pH, PaO2, PaCO2, bicarbonate (HCO3−), anion gap (AG) and base excess (BE) were monitored after chemical restraint, anesthesia induction and at different laparoscopy stages. Postoperative pain was assessed by visual analog scale (VAS) for 24 hours. Variables were compared using ANOVA or Friedman test (p < 0.05). Results: Chemical restraint was effective in 92% of animals. Isoflurane anesthesia was effective; however, HR, MAP, pH and AG decreased, whereas PE′CO2, PaO2, PaCO2, HCO3− and BE increased. MAP was stable with tramadol and methadone treatments; HR, FE′Iso and postoperative VAS decreased. VAS was lower for a longer time with methadone treatment; SpO2 and AG decreased, whereas PE′CO2, PaCO2 and HCO3− increased. Conclusions and clinical relevance: Ketamine–midazolam provided satisfactory restraint. Isoflurane anesthesia for laparoscopy was effective but resulted in hypotension and respiratory acidosis. Tramadol and methadone reduced isoflurane requirements, provided postoperative analgesia and caused hypercapnia, with methadone causing severe respiratory depression. Thus, the anesthetic protocol is adequate for laparoscopy in Cuniculus paca; however, methadone should be avoided. Institute of Agrarian Sciences Federal University of Jequithonha and Mucury Valleys (UFVJM) Department of Veterinary Pathobiology and Theriogenology São Paulo State University (Unesp) “Julio de Mesquita Filho” Department of Medicine and Veterinary Surgery Federal Rural University of Rio de Janeiro (UFRRJ) Department of Large Animal Clinic Federal University of Santa Maria (UFSM) Department of Veterinary Pathobiology and Theriogenology São Paulo State University (Unesp) “Julio de Mesquita Filho” CAPES: 14835126 FAPESP: FAPESP 2012/00724-6 |
| اللغة: | English |
| تدمد: | 1483-5126 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba961b22bdb242716f3d0a87e5e9c46e |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....ba961b22bdb242716f3d0a87e5e9c46e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14835126 |
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