Boys with Undescended Testes: Endocrine, Volumetric and Morphometric Studies on Testicular Function before and after Orchidopexy at Nine Months or Three Years of Age
| العنوان: | Boys with Undescended Testes: Endocrine, Volumetric and Morphometric Studies on Testicular Function before and after Orchidopexy at Nine Months or Three Years of Age |
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| المؤلفون: | Olle Söder, Mirja Nurmio, E. M. Ritzén, Agneta Nordenskjöld, Jorma Toppari, E. Sundqvist, T. Gustafsson, Jan-Bernd Stukenborg, Claude Kollin |
| المصدر: | The Journal of Clinical Endocrinology & Metabolism. 97:4588-4595 |
| بيانات النشر: | The Endocrine Society, 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Male, endocrine system, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, Clinical Biochemistry, Context (language use), Biology, Biochemistry, Endocrinology, Internal medicine, Cryptorchidism, Testis, Biopsy, medicine, Humans, Endocrine system, Inhibins, Testosterone, Hormone metabolism, Spermatogenesis, medicine.diagnostic_test, urogenital system, Biochemistry (medical), Age Factors, Infant, Newborn, Infant, Organ Size, Luteinizing Hormone, Sertoli cell, Hormones, Testicular function, medicine.anatomical_structure, Child, Preschool, Orchiopexy, Follicle Stimulating Hormone, Hormone |
| الوصف: | A randomized controlled study was conducted comparing the outcome of surgery for congenital cryptorchidism at 9 months or 3 yr of age.The aim of the study was to investigate whether surgery at 9 months is more beneficial than at 3 yr and to identify early endocrine markers of importance for testicular development.A total of 213 biopsies were taken at orchidopexy, and the number of germ and Sertoli cells per 100 seminiferous cord cross-sections and the surface area of seminiferous tubules and interstitial tissue were analyzed. Inhibin B, FSH, LH, and testosterone were determined. Testicular volume was assessed by ultrasonography and by a ruler.The number of germ and Sertoli cells and testicular volume at 9 months were significantly larger than at 3 yr. The intraabdominal testes showed the largest germ cell depletion at 3 yr. At both ages, testicular volume correlated to the number of germ and Sertoli cells. None of the hormones measured during the first 6 months of life (LH, FSH, testosterone, and inhibin B) could predict the number of germ or Sertoli cells at either 9 or 36 months of age, nor could hormone levels predict whether spontaneous descent would occur or not.Morphometric and volumetric data show that orchidopexy at 9 months is more beneficial for testicular development than an operation at 3 yr of age. Testicular volume was furthermore shown to reflect germ cell numbers in early childhood, whereas endocrine parameters could not predict cellular structure of the testis or its spontaneous descent. |
| تدمد: | 1945-7197 0021-972X |
| DOI: | 10.1210/jc.2012-2325 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9cb7b3e365663697afec697a2be2262 https://doi.org/10.1210/jc.2012-2325 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....b9cb7b3e365663697afec697a2be2262 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19457197 0021972X |
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| DOI: | 10.1210/jc.2012-2325 |