Association between body mass index and breast cancer intrinsic subtypes in Japanese women
| العنوان: | Association between body mass index and breast cancer intrinsic subtypes in Japanese women |
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| المؤلفون: | Satoru Tanaka, Mitsuhiko Iwamoto, Hiroya Fujioka, Nayuko Satou, Yuko Takahashi, Kosei Kimura, Kazuhisa Uchiyama |
| المصدر: | Experimental and Therapeutic Medicine |
| بيانات النشر: | D.A. Spandidos, 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Cancer Research, medicine.medical_specialty, Pathology, intrinsic subtype, Estrogen receptor, body mass index, Gastroenterology, Breast cancer, breast cancer, Immunology and Microbiology (miscellaneous), Internal medicine, Progesterone receptor, medicine, case-only analysis, Japanese population, business.industry, Cancer, General Medicine, Odds ratio, Articles, medicine.disease, Etiology, Underweight, medicine.symptom, business, Body mass index |
| الوصف: | The purpose of this study was to examine the association between body mass index (BMI) and breast cancer intrinsic subtypes in Japanese women. A more complete understanding of the subtypes of breast cancer may elucidate the mechanisms affecting the etiology and mortality associated with each subtype. Tumor data on 531 invasive breast cancer cases subtyped by estrogen receptor, progesterone receptor and human epidermal growth factor receptor 2 (Her2) status were obtained [luminal A, luminal B, triple-negative (TN) and Her2-type]. Demographics (age at diagnosis, menopausal status and BMI) were collected from medical records. Case-only odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using logistic regression, adjusting for age at diagnosis. Of the 531 cases, 333 (62.7%) were luminal A, 85 (16.0%) were luminal B, 43 (8.1%) were Her2-type and 70 (13.2%) were TN. Compared with luminal A cases, premenopausal TN cases were more likely to be obese (OR, 4.11; 95% CI, 1.10–14.40), while postmenopausal TN cases were more likely to be underweight (OR, 3.14; 95% CI, 1.19–8.01). Premenopausal luminal B cases were likely to be underweight or obese, while luminal B and Her2-type cases were likely to be underweight. In the present study, significant heterogeneity of associations between BMI and tumor subtypes was observed. Breast cancer subtypes may have various etiologies associated with each subtype. |
| اللغة: | English |
| تدمد: | 1792-1015 1792-0981 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9af42e3dd2e03ba60d39c91e6be9737 http://europepmc.org/articles/PMC3503533 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....b9af42e3dd2e03ba60d39c91e6be9737 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17921015 17920981 |
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