Combined bioavailable isoflavones and probiotics improve bone status and estrogen metabolism in postmenopausal osteopenic women:a randomized controlled trial
| العنوان: | Combined bioavailable isoflavones and probiotics improve bone status and estrogen metabolism in postmenopausal osteopenic women:a randomized controlled trial |
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| المؤلفون: | Xavier Fretté, Catrine Bundgaard Thybo, Max Norman Tandrup Lambert, Lars Porskjær Christensen, Per Bendix Jeppesen, Simon Lykkeboe, Lars Melholt Rasmussen |
| المصدر: | Lambert, M N T, Thybo, C B, Lykkeboe, S, Rasmussen, L M, Frette, X, Christensen, L P & Jeppesen, P B 2017, ' Combined bioavailable isoflavones and probiotics improve bone status and estrogen metabolism in postmenopausal osteopenic women : a randomized controlled trial ', The American Journal of Clinical Nutrition, vol. 106, no. 3, pp. 909-920 . https://doi.org/10.3945/ajcn.117.153353 Lambert, M N T, Thybo, C B, Lykkeboe, S, Rasmussen, L M, Fretté, X, Porskjær Christensen, L & Jeppesen, P B 2017, ' Combined bioavailable isoflavones and probiotics improve bone status and estrogen metabolism in postmenopausal osteopenic women: a randomized controlled trial ', American Journal of Clinical Nutrition . https://doi.org/10.3945/ajcn.117.153353 Lambert, M N T, Thybo, C B, Lykkeboe, S, Rasmussen, L M, Fretté, X, Christensen, L P & Jeppesen, P B 2017, ' Combined bioavailable isoflavones and probiotics improve bone status and estrogen metabolism in post-menopausal osteopenic women: a randomized controlled trial ', American Journal of Clinical Nutrition, vol. 106, no. 3, pp. 909-920 . https://doi.org/10.3945/ajcn.117.153353 |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, Osteoporosis, Postmenopausal/metabolism, Bone density, Bioavailability, Peptides/blood, Osteoporosis, Medicine (miscellaneous), Estrogen receptor, Bone remodeling, chemistry.chemical_compound, 0302 clinical medicine, Bone Density, Isoflavones/blood, Intestinal Mucosa, Trifolium/chemistry, Osteoporosis, Postmenopausal, Nutrition and Dietetics, Bone Density Conservation Agents, Estrogens/deficiency, Selective Estrogen Receptor Modulators/pharmacology, Probiotics/therapeutic use, Equol, Middle Aged, Isoflavone, Bone Diseases, Metabolic/drug therapy, Postmenopause, Intestines, Drug Combinations, Female, Bone Remodeling, medicine.drug, Selective Estrogen Receptor Modulators, medicine.medical_specialty, Bone turnover, Calcitriol, medicine.drug_class, Collagen Type I/blood, Biological Availability, 030209 endocrinology & metabolism, Intestines/drug effects, Bone and Bones, Collagen Type I, 03 medical and health sciences, Double-Blind Method, Internal medicine, medicine, Journal Article, Humans, Bone Density Conservation Agents/pharmacology, business.industry, Osteopenia, Plant Extracts, Probiotics, Plant Extracts/pharmacology, Bone and Bones/drug effects, Bone Density/drug effects, Estrogens, medicine.disease, Isoflavones, Gastrointestinal Microbiome, Bone Diseases, Metabolic, 030104 developmental biology, Endocrinology, chemistry, Estrogen, Bone Remodeling/drug effects, Trifolium, business, Peptides, Intestinal Mucosa/metabolism, Phytotherapy |
| الوصف: | Background: Female age-related estrogen deficiency increases the risk of osteoporosis, which can be effectively treated with the use of hormone replacement therapy. However, hormone replacement therapy is demonstrated to increase cancer risk. Bioavailable isoflavones with selective estrogen receptor affinity show potential to prevent and treat osteoporosis while minimizing or eliminating carcinogenic side effects.Objective: In this study, we sought to determine the beneficial effects of a bioavailable isoflavone and probiotic treatment against postmenopausal osteopenia. Design: We used a novel red clover extract (RCE) rich in isoflavone aglycones and probiotics to concomitantly promote uptake and a favorable intestinal bacterial profile to enhance isoflavone bioavailability. This was a 12-mo, double-blind, parallel design, placebo-controlled, randomized controlled trial of 78 postmenopausal osteopenic women supplemented with calcium (1200 mg/d), magnesium (550 mg/d), and calcitriol (25 mg/d) given either RCE (60 mg isoflavone aglycones/d and probiotics) or a masked placebo [control (CON)].Results: RCE significantly attenuated bone mineral density (BMD) loss at the L2–L4 lumbar spine vertebra (P , 0.05), femoral neck (P , 0.01), and trochanter (P , 0.01) compared with CON (20.99% and 22.2%; 21.04% and 23.05%; and 20.67% and 22.79, respectively). Plasma concentrations of collagen type 1 cross-linked C-telopeptide was significantly decreased in the RCE group (P , 0.05) compared with CON (29.40% and 26.76%, respectively). RCE significantly elevated the plasma isoflavone concentration (P , 0.05), the urinary 2-hydroxyestrone (2-OH) to 16a-hydroxyestrone (16a-OH) ratio (P , 0.05), and equol-producer status (P , 0.05) compared with CON. RCE had no significant effect on other bone turnover biomarkers. Self-reported diet and physical activity were consistent and differences were nonsignificant between groups throughout the study. RCE was well tolerated with no adverse events.Conclusions: Twice daily RCE intake over 1 y potently attenuated BMD loss caused by estrogen deficiency, improved bone turnover, promoted a favorable estrogen metabolite profile (2-OH:16a-OH), and stimulated equol production in postmenopausal women with osteopenia. RCE intake combined with upplementation (calcium, magnesium, and calcitriol) was more effective than supplementation alone. This trial was registered at clinicaltrials.gov as NCT02174666. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| DOI: | 10.3945/ajcn.117.153353 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b986b8e618f81e2d874a8ac70951e57a https://vbn.aau.dk/da/publications/c1aa5a63-f0f0-4eb9-8797-b3c3f335d621 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....b986b8e618f81e2d874a8ac70951e57a |
| قاعدة البيانات: | OpenAIRE |
| DOI: | 10.3945/ajcn.117.153353 |
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