A population of proinflammatory T cells coexpresses αβ and γδ T cell receptors in mice and humans
| العنوان: | A population of proinflammatory T cells coexpresses αβ and γδ T cell receptors in mice and humans |
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| المؤلفون: | Jesus Paez-Cortez, Paul G. Thomas, Song Baik, David Price, Karsten Hokamp, Sarah C. Edwards, Bruno Silva-Santos, Rachel M. McLoughlin, Stephen J. Lalor, Valerie Pivorunas, Caroline E. Sutton, Graham Anderson, Walid Awad, Barry Moran, Julie C. Ribot, James E. McLaren, Aoife M. McGinley, Anthony Slavin, Fiona M. Roche, Pradyot Dash, Kristin Ladell, Nopporn Apiwattanakul, Kingston H. G. Mills, Michael Macoritto, Kelly L. Miners, Lori Dowding, Emma J. Grant |
| المصدر: | The Journal of Experimental Medicine Journal of Experimental Medicine |
| بيانات النشر: | Rockefeller University Press, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Staphylococcus aureus, Encephalomyelitis, Autoimmune, Experimental, Transcription, Genetic, Receptors, Antigen, T-Cell, alpha-beta, T-Lymphocytes, T cell, Immunology, Population, Autoimmunity, Biology, Lymphocyte Activation, 03 medical and health sciences, Chemokine receptor, 0302 clinical medicine, Neuroinflammation, Antigen, medicine, Animals, Humans, Immunology and Allergy, education, 030304 developmental biology, Inflammation, 0303 health sciences, education.field_of_study, T-cell receptor, Brief Definitive Report, Receptors, Antigen, T-Cell, gamma-delta, Staphylococcal Infections, 3. Good health, Cell biology, Mice, Inbred C57BL, Phenotype, medicine.anatomical_structure, Interleukin 17, Transcriptome, Biomarkers, CD8, 030215 immunology |
| الوصف: | T cells classically express either αβ or γδ T cell receptors. We have identified T cells that express both pairs of receptors. These hybrid αβ-γδ T cells exhibit a hyperinflammatory and migratory phenotype and act as first responders in infection and CNS autoimmunity. T cells are classically recognized as distinct subsets that express αβ or γδ TCRs. We identify a novel population of T cells that coexpress αβ and γδ TCRs in mice and humans. These hybrid αβ-γδ T cells arose in the murine fetal thymus by day 16 of ontogeny, underwent αβ TCR–mediated positive selection into CD4+ or CD8+ thymocytes, and constituted up to 10% of TCRδ+ cells in lymphoid organs. They expressed high levels of IL-1R1 and IL-23R and secreted IFN-γ, IL-17, and GM-CSF in response to canonically restricted peptide antigens or stimulation with IL-1β and IL-23. Hybrid αβ-γδ T cells were transcriptomically distinct from conventional γδ T cells and displayed a hyperinflammatory phenotype enriched for chemokine receptors and homing molecules that facilitate migration to sites of inflammation. These proinflammatory T cells promoted bacterial clearance after infection with Staphylococcus aureus and, by licensing encephalitogenic Th17 cells, played a key role in the development of autoimmune disease in the central nervous system. Graphical Abstract |
| وصف الملف: | application/pdf |
| تدمد: | 1540-9538 0022-1007 |
| DOI: | 10.1084/jem.20190834 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b959b0b0d180f391caec4c75edeeac7c https://doi.org/10.1084/jem.20190834 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....b959b0b0d180f391caec4c75edeeac7c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15409538 00221007 |
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| DOI: | 10.1084/jem.20190834 |