Differential contribution of excitatory and inhibitory neurons in shaping neurovascular coupling in different epileptic neural states
| العنوان: | Differential contribution of excitatory and inhibitory neurons in shaping neurovascular coupling in different epileptic neural states |
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| المؤلفون: | Bok-Man Kang, Seong-Gi Kim, Minah Suh, Nayeon You, Sungjun Bae, H. Lim, Young-Min Shon |
| المصدر: | Journal of Cerebral Blood Flow & Metabolism |
| بيانات النشر: | SAGE Publications, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Male, neurovascular coupling, cerebral blood flow, Neuroimaging, Local field potential, Inhibitory postsynaptic potential, Mice, 03 medical and health sciences, Epilepsy, 0302 clinical medicine, Calcium imaging, Seizures, excitatory neuron, inhibitory neuron, medicine, Animals, Premovement neuronal activity, Ictal, 030304 developmental biology, Neurons, Photons, 0303 health sciences, Chemistry, Hemodynamics, Original Articles, medicine.disease, Electrophysiology, Mice, Inbred C57BL, Arterioles, calcium imaging, nervous system, Neurology, Cerebral blood flow, Cerebrovascular Circulation, Models, Animal, Excitatory postsynaptic potential, in vivo two-photon imaging, Calcium, Neurology (clinical), Cardiology and Cardiovascular Medicine, Neuroscience, 030217 neurology & neurosurgery |
| الوصف: | Understanding the neurovascular coupling (NVC) underlying hemodynamic changes in epilepsy is crucial to properly interpreting functional brain imaging signals associated with epileptic events. However, how excitatory and inhibitory neurons affect vascular responses in different epileptic states remains unknown. We conducted real-time in vivo measurements of cerebral blood flow (CBF), vessel diameter, and excitatory and inhibitory neuronal calcium signals during recurrent focal seizures. During preictal states, decreases in CBF and arteriole diameter were closely related to decreased γ-band local field potential (LFP) power, which was linked to relatively elevated excitatory and reduced inhibitory neuronal activity levels. Notably, this preictal condition was followed by a strengthened ictal event. In particular, the preictal inhibitory activity level was positively correlated with coherent oscillating activity specific to inhibitory neurons. In contrast, ictal states were characterized by elevated synchrony in excitatory neurons. Given these findings, we suggest that excitatory and inhibitory neurons differentially contribute to shaping the ictal and preictal neural states, respectively. Moreover, the preictal vascular activity, alongside with the γ-band, may reflect the relative levels of excitatory and inhibitory neuronal activity, and upcoming ictal activity. Our findings provide useful insights into how perfusion signals of different epileptic states are related in terms of NVC. |
| تدمد: | 1559-7016 0271-678X |
| DOI: | 10.1177/0271678x20934071 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8f53a1802669561f7bb66346ffbb2d3 https://doi.org/10.1177/0271678x20934071 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....b8f53a1802669561f7bb66346ffbb2d3 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15597016 0271678X |
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| DOI: | 10.1177/0271678x20934071 |