Recurrent gain of chromosome arm 7q in low-grade astrocytic tumors studied by comparative genomic hybridization
| العنوان: | Recurrent gain of chromosome arm 7q in low-grade astrocytic tumors studied by comparative genomic hybridization |
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| المؤلفون: | Gundula Thiel, Regine Witkowski, Evelin Schröck, Tanka Lozanowa, Thomas Ried, Collin Blume, Marie-Christine Meffert, Wolf Bersch, Thomas Cremer, Stanislas du Manoir, Marika Kiessling |
| المصدر: | Genes, Chromosomes and Cancer. 15:199-205 |
| بيانات النشر: | Wiley, 1996. |
| سنة النشر: | 1996 |
| مصطلحات موضوعية: | Adult, Male, Cancer Research, Pathology, medicine.medical_specialty, Adolescent, Tumor suppressor gene, Astrocytoma, Biology, Loss of heterozygosity, chemistry.chemical_compound, Turner syndrome, Genetics, medicine, Humans, Child, X chromosome, Chromosome Aberrations, Brain Neoplasms, Nucleic Acid Hybridization, Middle Aged, Dna amplification, medicine.disease, Molecular biology, Chromosome Banding, chemistry, Child, Preschool, Karyotyping, Chromosome Arm, Female, Chromosomes, Human, Pair 7, DNA, Comparative genomic hybridization |
| الوصف: | Consistent tumor-specific chromosomal aberrations have not been described in low-grade astrocytic tumors. The most frequent genetic alterations are mutations of the TP53 tumor suppressor gene and/or loss of heterozygosity (LOH) on 17p that occur in about 30% of the cases in adult patients but that are uncommon in childhood tumors. We used comparative genomic hybridization (CGH) to map DNA copy number alterations in 18 primary low-grade astrocytic tumors (ten adult patients and eight children). A gain of chromosome arm 7q was the most frequent event detected in five of ten astrocytomas (50%) from adult patients, followed by DNA amplification on chromosome arm 8q and gain on 12p (two cases). Loss of chromosomal regions on 1p, 4q, and the X chromosome was observed in two of ten cases [including one patient afflicted with Turner syndrome (45,X)]. In contrast, no consistent changes were observed in low-grade astrocytomas in children. A loss of the X chromosome was the sole aberration detected in two of eight cases using DNA extracted from the normal brain tissue. The findings suggest that a gain of 7q is an early event in the initiation of astrocytomas in adult patients. The discrepant findings in low-grade astrocytic tumors in adults compared to tumors in children support the the hypothesis that there might be different mechanisms responsible for tumor development. |
| تدمد: | 1098-2264 1045-2257 |
| DOI: | 10.1002/(sici)1098-2264(199604)15:4<199::aid-gcc1>3.0.co;2-x |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8c8ccad7689148a3a7126b270f00879 https://doi.org/10.1002/(sici)1098-2264(199604)15:4<199::aid-gcc1>3.0.co;2-x |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....b8c8ccad7689148a3a7126b270f00879 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10982264 10452257 |
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| DOI: | 10.1002/(sici)1098-2264(199604)15:4<199::aid-gcc1>3.0.co;2-x |