Risk Factors for Weight Gain Following Switch to Integrase Inhibitor–Based Antiretroviral Therapy
| العنوان: | Risk Factors for Weight Gain Following Switch to Integrase Inhibitor–Based Antiretroviral Therapy |
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| المؤلفون: | Grace A. McComsey, Frank J. Palella, Paula Debroy, Kristine M. Erlandson, Catherine Godfrey, Jordan E. Lake, Katherine Tassiopoulos, John R. Koethe, Kunling Wu, Sara H Bares |
| المصدر: | Clin Infect Dis |
| بيانات النشر: | Oxford University Press (OUP), 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, Microbiology (medical), medicine.medical_specialty, Waist, 030106 microbiology, Integrase inhibitor, HIV Infections, Weight Gain, 03 medical and health sciences, 0302 clinical medicine, Acquired immunodeficiency syndrome (AIDS), Risk Factors, Internal medicine, Diabetes mellitus, medicine, Humans, HIV Integrase Inhibitors, 030212 general & internal medicine, Online Only Articles, Aged, business.industry, medicine.disease, Circumference, Antiretroviral therapy, Infectious Diseases, Concomitant, Female, medicine.symptom, business, Weight gain |
| الوصف: | Background Treatment initiation with integrase strand transfer inhibitors (INSTIs) has been associated with excess weight gain. Whether similar gains are seen after switch to INSTIs among virologically suppressed persons is less clear. We assessed pre/post-INSTI weight changes from AIDS Clinical Trials Group participants (A5001 and A5322). Methods Participants who were in follow-up from 1997–2017 and switched to INSTI-based antiretroviral regimens were included. Piecewise linear mixed-effects models adjusting for age, sex, race/ethnicity, baseline BMI, nadir and current CD4+ T-cell count, smoking, diabetes and follow-up time with suppressed HIV-1 RNA examined weight and waist circumference change before and after first switch to INSTIs. Linear spline models with a single knot at time of switch accounted for nonlinear trends. Results The 972 participants who switched to INSTIs were 81% male and 50% nonwhite with a median age at switch of 50 years, CD4+ T-cell count 512 cells/μL, and BMI 26.4 kg/m2. Restricting to persons with suppressed HIV-1 RNA at switch (n = 691), women, blacks, and persons ≥60 years experienced greater weight gain in the 2 years after versus before switch. In adjusted models, white or black race, age ≥60, and BMI ≥30 kg/m2 at switch were associated with greater weight gain following switch among women; age ≥60 was the greatest risk factor among men. Trends for waist circumference were similar. Conclusions Yearly weight gain increased following switch to INSTIs, particularly for women, blacks, and persons aged ≥60. Concomitant increases in waist circumference suggest that this weight gain is associated with an increase in fat mass. |
| تدمد: | 1537-6591 1058-4838 |
| DOI: | 10.1093/cid/ciaa177 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b878b299abef3de203c5653576bcf1c3 https://doi.org/10.1093/cid/ciaa177 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....b878b299abef3de203c5653576bcf1c3 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15376591 10584838 |
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| DOI: | 10.1093/cid/ciaa177 |