Intradermal vaccination of pigs against FMD with 1/10 dose results in comparable vaccine efficacy as intramuscular vaccination with a full dose
| العنوان: | Intradermal vaccination of pigs against FMD with 1/10 dose results in comparable vaccine efficacy as intramuscular vaccination with a full dose |
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| المؤلفون: | K. Weerdmeester, P.L. Eblé, Aldo Dekker, F. van Hemert-Kluitenberg |
| المصدر: | Vaccine, 27(8), 1272-1278 Vaccine 27 (2009) 8 |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | Hepatitis B vaccine, Injections, Intradermal, Swine, virus, Antibodies, Viral, antibody-responses, Injections, Intramuscular, Severity of Illness Index, mouth-disease vaccines, Immune system, antigen, CVI - Divisie Virologie, Antigen, Neutralization Tests, medicine, Animals, immune-responses, Viral shedding, Swine Diseases, aujeszkys-disease, hepatitis-b-vaccine, General Veterinary, General Immunology and Microbiology, Foot-and-mouth disease, business.industry, Public Health, Environmental and Occupational Health, Viral Vaccines, medicine.disease, Vaccine efficacy, protection, Virology, infection, Virus Shedding, Vaccination, Infectious Diseases, Immunization, Foot-and-Mouth Disease Virus, Foot-and-Mouth Disease, Immunology, Molecular Medicine, business, influenza, CVI - Division Virology |
| الوصف: | The aim of this study was to investigate whether intradermal (ID) vaccination against foot-and-mouth disease (FMD) is suitable as an alternative for the usually used intramuscular (IM) route. We compared vaccine efficacy in groups of pigs in which vaccine administration differed with respect to antigen payload of the vaccine, administrated volume and administration route. When compared with pigs that were IM vaccinated with a full dose vaccine with a standard antigen payload, pigs vaccinated ID with 1/10 dose of the same vaccine were equally protected against clinical disease and subclinical virus shedding. The ID vaccinated pigs were protected against virus shedding at a significant lower VN-titre as compared to IM vaccinated pigs, suggesting that immune responses other than neutralising antibodies also contributed to protection. We conclude that the ID route might be a good alternative for IM application, as ID application might induce a very efficient immunological response against FMD and, moreover, because the dose required by the ID route is lower compared to the IM route, ID application may reduce the production costs per dose of FMD vaccine markedly. |
| وصف الملف: | application/octet-stream; application/pdf |
| اللغة: | English |
| تدمد: | 0264-410X |
| DOI: | 10.1016/j.vaccine.2008.12.011 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b787bf69f02a2249e2e11814b40a0c89 https://doi.org/10.1016/j.vaccine.2008.12.011 |
| Rights: | RESTRICTED |
| رقم الانضمام: | edsair.doi.dedup.....b787bf69f02a2249e2e11814b40a0c89 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 0264410X |
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| DOI: | 10.1016/j.vaccine.2008.12.011 |