Evidence of a Significant Role for Fas-Mediated Apoptosis in HCV Clearance during Pegylated Interferon plus Ribavirin Combination Therapy
| العنوان: | Evidence of a Significant Role for Fas-Mediated Apoptosis in HCV Clearance during Pegylated Interferon plus Ribavirin Combination Therapy |
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| المؤلفون: | Claudia Teresa Carvente, Genimari Arruda da Silva, Philipe Nicolas El Batah, Maria Lucia Gomes Ferraz, Antonio Eduardo Benedito Silva, Leonardo de Lucca Schiavon, Roberto J. Carvalho-Filho, Janaína Luz Narciso-Schiavon, Juliana P. Sampaio |
| المساهمون: | Universidade Federal de São Paulo (UNIFESP) |
| المصدر: | Repositório Institucional da UNIFESP Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
| بيانات النشر: | SAGE Publications, 2010. |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | Adult, Male, Programmed cell death, Fas Ligand Protein, Combination therapy, Hepatitis C virus, medicine.medical_treatment, Apoptosis, Hepacivirus, Interferon alpha-2, Pharmacology, medicine.disease_cause, Antiviral Agents, Polyethylene Glycols, chemistry.chemical_compound, Interferon, Pegylated interferon, Ribavirin, medicine, Humans, Pharmacology (medical), fas Receptor, business.industry, Interferon-alpha, Hepatitis C, Chronic, Middle Aged, Recombinant Proteins, digestive system diseases, Cross-Sectional Studies, Treatment Outcome, Infectious Diseases, Cytokine, chemistry, Receptors, Tumor Necrosis Factor, Type I, Immunology, Drug Therapy, Combination, Female, business, medicine.drug |
| الوصف: | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Background: the role of apoptosis in treatment-induced HCV clearance is controversial. We sought to assess the kinetics of serum apoptosis-related cytokines during pegylated interferon-alpha 2a or -alpha 2b plus weight-based ribavirin therapy for genotype 1 chronic HCV infection.Methods: Serum levels of soluble Fas (sFas), soluble Fas ligand (sFasL) and soluble tumour necrosis factor receptor I (sTNF-RI) were measured at baseline, week 12 and 24 weeks after the end of therapy.Results: Sustained virological response (SVR) was achieved in 46% of the 164 included patients, 29% had a non-response (NR) and 25% had relapse (RR). NR patients presented with higher levels of sFasL at baseline and lower levels of sTNF-RI at week 12 as compared to RR and SVR patients. Lower concentrations of sFas were observed in SVR patients 24 weeks after treatment as compared to RR and NR patients. An increase in sFas at week 12 followed by a significant drop 24 weeks after therapy was observed among SVR patients. An increase in sFasL during and after treatment was observed in RR and SVR patients. NR patients exhibited an earlier drop in sTNF-RI levels as compared to RR and SVR patients.Conclusions: Virological response during HCV therapy was associated with an increase of sFas and sFasL, and maintenance of increased concentrations of sTNF-RI. Universidade Federal de São Paulo, Hepatitis Sect, Div Gastroenterol, São Paulo, Brazil Universidade Federal de São Paulo, Hepatitis Sect, Div Gastroenterol, São Paulo, Brazil Web of Science |
| تدمد: | 2040-2058 1359-6535 |
| DOI: | 10.3851/imp1768 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b75660ecfc5fd36f3d390ee39ca64249 https://doi.org/10.3851/imp1768 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....b75660ecfc5fd36f3d390ee39ca64249 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20402058 13596535 |
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| DOI: | 10.3851/imp1768 |