التفاصيل البيبلوغرافية
| العنوان: |
Interferon-α-Induced Endogenous Superantigen |
| المؤلفون: |
Brigitte T. Huber, Bernard Conrad, Samuel Marguerat, Thierry Pelet, Natalie Sutkowski, Françoise Meylan, Catherine Ucla, Yves Stauffer |
| المصدر: |
Immunity. 15(4):591-601 |
| بيانات النشر: |
Elsevier BV, 2001. |
| سنة النشر: |
2001 |
| مصطلحات موضوعية: |
Genetically modified mouse, viruses, Immunology, Alpha interferon, chemical and pharmacologic phenomena, Endogeny, Transfection, Biology, Provirus, medicine.disease_cause, Virology, Autoimmunity, body regions, Infectious Diseases, Antigen, embryonic structures, parasitic diseases, Superantigen, medicine, Immunology and Allergy |
| الوصف: |
We earlier proposed that a human endogenous retroviral (HERV) superantigen (SAg) IDDMK(1,2)22 may cause type I diabetes by activating autoreactive T cells. Viral infections and induction of interferon-alpha (IFN-alpha) are tightly associated with the onset of autoimmunity. Here we establish a link between viral infections and IFN-alpha-regulated SAg expression of the polymorphic and defective HERV-K18 provirus. HERV-K18 has three alleles, IDDMK(1,2)22 and two full-length envelope genes, that all encode SAgs. Expression of HERV-K18 SAgs is inducible by IFN-alpha and this is sufficient to stimulate V beta 7 T cells to levels comparable to transfectants constitutively expressing HERV-K18 SAgs. Endogenous SAgs induced via IFN-alpha by viral infections is a novel mechanism through which environmental factors may cause disease in genetically susceptible individuals. |
| تدمد: |
1074-7613 |
| DOI: |
10.1016/s1074-7613(01)00212-6 |
| URL الوصول: |
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b698720e39f118fcf123baf50886e86b |
| Rights: |
OPEN |
| رقم الانضمام: |
edsair.doi.dedup.....b698720e39f118fcf123baf50886e86b |
| قاعدة البيانات: |
OpenAIRE |