Liquid Chromatographic Analysis of Incurred Amoxicillin Residues in Catfish Muscle Following Oral Administration of the Drug
| العنوان: | Liquid Chromatographic Analysis of Incurred Amoxicillin Residues in Catfish Muscle Following Oral Administration of the Drug |
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| المؤلفون: | Catharina Y. W. Ang, Theresa Gehring, Jack O. Lay, Rebecca Lochmann, Frances F. Liu, Wenhong Luo, Karen McKim |
| المصدر: | Journal of Agricultural and Food Chemistry. 48:1673-1677 |
| بيانات النشر: | American Chemical Society (ACS), 2000. |
| سنة النشر: | 2000 |
| مصطلحات موضوعية: | medicine.drug_class, Antibiotics, Administration, Oral, Penicillins, Residue (chemistry), Pharmacokinetics, Aquaculture, Oral administration, medicine, Animals, Chromatography, High Pressure Liquid, Detection limit, Chromatography, Chemistry, business.industry, Muscles, Amoxicillin, General Chemistry, Drug Residues, Ictaluridae, Spectrometry, Fluorescence, General Agricultural and Biological Sciences, business, medicine.drug, Catfish |
| الوصف: | Improper application of antibiotic chemicals to livestock and aquaculture species may lead to the occurrence of residues in food supplies. An appropriate depletion period is needed after the administration of drugs to animals for ensuring that residues in edible tissues are below established tolerance levels. This study was conducted to determine incurred amoxicillin residues in catfish muscle following oral administration. Dosed fish were harvested after four depletion periods, and muscle fillets were analyzed for amoxicillin residues using an HPLC method with precolumn derivatization and fluorescence detection. The residue levels in fish after a 6-h depletion ranged from 40 to 64 ng/g with one exception at 297 ng/g. Average residue levels decreased to 5.4 and 2. 8 ng/g after 24- and 48-h depletions, respectively. Residue levels after a 72-h depletion decreased to below the method's limit of quantitation (1.2 ng/g). An LC-MS/MS confirmatory method was developed. Confirmation of the presence of amoxicillin was demonstrated in incurred fish samples containing residues at approximately 50-300 ng/g. |
| تدمد: | 1520-5118 0021-8561 |
| DOI: | 10.1021/jf990410a |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6908ef89729db925231d74bd2c91880 https://doi.org/10.1021/jf990410a |
| رقم الانضمام: | edsair.doi.dedup.....b6908ef89729db925231d74bd2c91880 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15205118 00218561 |
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| DOI: | 10.1021/jf990410a |