Analysis of an evolutionarily conserved antigenic site on mammalian cytochrome c using synthetic peptides
| العنوان: | Analysis of an evolutionarily conserved antigenic site on mammalian cytochrome c using synthetic peptides |
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| المؤلفون: | Ronald Jemmerson, Phillip R. Morrow, Norman R. Klinman, Yvonne Paterson |
| المصدر: | Proceedings of the National Academy of Sciences. 82:1508-1512 |
| بيانات النشر: | Proceedings of the National Academy of Sciences, 1985. |
| سنة النشر: | 1985 |
| مصطلحات موضوعية: | Antigenicity, Hemeprotein, Cytochrome c Group, Peptide, Context (language use), Biology, environment and public health, Epitope, Epitopes, Antibody Specificity, Animals, Amino Acid Sequence, Peptide sequence, chemistry.chemical_classification, Multidisciplinary, Tetrapeptide, Cytochrome c, Biological Evolution, enzymes and coenzymes (carbohydrates), chemistry, Biochemistry, Antibody Formation, embryonic structures, cardiovascular system, biology.protein, Rabbits, Oligopeptides, Research Article |
| الوصف: | Two synthetic peptides inclusive of the NH2-terminal N-acetyl-Gly-Asp-Val-Glu tetrapeptide of mammalian cytochrome c (cyt c) were used in this study to address the question of whether mammals can respond immunologically to an evolutionarily conserved region of a protein. These peptides were assessed for their capacity (i) to act as immunogens for the production of anti-self cyt c antisera and (ii) to bind rabbit anti-rodent cyt c antibody. The findings from these studies indicate the existence of an immunogenic determinant in an evolutionarily conserved region of cyt c that contains residues 1-4. This determinant can induce anti-self cyt c antibodies whether presented as a peptide on a carrier protein or in the context of the intact molecule as polymerized mammalian cyt c. |
| تدمد: | 1091-6490 0027-8424 |
| DOI: | 10.1073/pnas.82.5.1508 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b670ecd3e4e8411f8d8379640c0c3c45 https://doi.org/10.1073/pnas.82.5.1508 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....b670ecd3e4e8411f8d8379640c0c3c45 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10916490 00278424 |
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| DOI: | 10.1073/pnas.82.5.1508 |