Human herpesvirus-8 infection in Tunisian adult acute leukemia patients
| العنوان: | Human herpesvirus-8 infection in Tunisian adult acute leukemia patients |
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| المؤلفون: | Imene Handous, Naila Hannachi, Bechir Achour, Manel Marzouk, Olfa Hazgui, Saloua Yacoub, Abderrahim Khelif, Jalel Boukadida |
| المصدر: | African Health Sciences; Vol. 23 No. 1 (2023); 504-10 |
| بيانات النشر: | Makerere University Medical School (Uganda), 2023. |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | General Medicine, Human herpesvirus 8, acute leukemia patients, blood donors, prevalence |
| الوصف: | Background: Human herpesvirus 8 (HHV-8) has been linked to the development of Kaposi's sarcoma (KS)and multiple other hematologic malignant disorders. However, the role of HHV-8 in acute leukemia patients is unknown. Objectives: The objective of this study was to determine the prevalence of HHV-8 in Tunisian acute leukemia patients and in healthy blood donors. Methods: An indirect immunofluorescence test was used to detect the presence of anti-HHV8 antibodies. Nested PCR was used for the detection of HHV-8 DNAemia in samples of plasma. Results: The seroprevalence of HHV-8 was significantly higher in acute leukemia patients (21,4% ,15/70) than in healthy blood donors (7,1%, 5/70), (p= 0.02). Gender, type of disease, status of disease, prior blood transfusion, and outcome were not associated with HHV-8 seroprevalence. However, among acute leukemia patients, HHV-8 seroprevalence was statistically associated with older age > 40 years of age, (p=0.002). HHV-8 DNAemia was detected (1,4%) in only one patient of acute myeloid leukemia (AML) and none of the healthy blood donors. Conclusions: The seroprevalence of HHV-8 infection in Tunisian adult acute leukemia patients was three times as high compared to healthy blood donors, suggesting that patients with acute leukemia might be at increased risk of HHV-8 infection. Keywords: Human herpesvirus 8; acute leukemia patients; blood donors; prevalence. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1680-6905 1729-0503 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b592eff519e5d3fc54b0f202a206a0e8 https://www.ajol.info/index.php/ahs/article/view/245593 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....b592eff519e5d3fc54b0f202a206a0e8 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16806905 17290503 |
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