Neoadjuvant chemotherapy with docetaxel and carboplatin followed by radical hysterectomy for stage IB2, IIA2, and IIB patients with non-squamous cell carcinoma of the uterine cervix
| العنوان: | Neoadjuvant chemotherapy with docetaxel and carboplatin followed by radical hysterectomy for stage IB2, IIA2, and IIB patients with non-squamous cell carcinoma of the uterine cervix |
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| المؤلفون: | Junzo Kigawa, Toru Sugiyama, Shoji Nagao, Muneaki Shimada, Keiichi Fujiwara, Satoshi Yamaguchi, Ryuichiro Nishimura, Nobuhiro Takeshima, Ken Takizawa, Tadahiro Shoji |
| المصدر: | International Journal of Clinical Oncology. 21:1128-1135 |
| بيانات النشر: | Springer Science and Business Media LLC, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Oncology, medicine.medical_treatment, Uterine Cervical Neoplasms, Phases of clinical research, Docetaxel, urologic and male genital diseases, Carboplatin, chemistry.chemical_compound, 0302 clinical medicine, Antineoplastic Combined Chemotherapy Protocols, 030212 general & internal medicine, Neoadjuvant therapy, Hematology, General Medicine, Middle Aged, Prognosis, Neoadjuvant Therapy, female genital diseases and pregnancy complications, Survival Rate, Treatment Outcome, 030220 oncology & carcinogenesis, Female, Taxoids, therapeutics, medicine.drug, Adult, medicine.medical_specialty, Neutropenia, Antineoplastic Agents, Hysterectomy, 03 medical and health sciences, Internal medicine, Carcinoma, medicine, Humans, Radical Hysterectomy, neoplasms, Aged, Neoplasm Staging, Chemotherapy, Dose-Response Relationship, Drug, business.industry, organic chemicals, medicine.disease, chemistry, Surgery, business |
| الوصف: | We conducted a phase II study to evaluate the efficacy of neoadjuvant chemotherapy with docetaxel and carboplatin followed by radical hysterectomy for patients with non-squamous cell carcinoma of the uterine cervix.Sixty-one patients with International Federation of Gynecology and Obstetrics stage IB2, IIA2, or IIB non-squamous cell carcinoma of the uterine cervix were enrolled. The patients were administered docetaxel at a dose of 60 mg/mThe response rate was 69 % (95 % CI, 57-82 %), with 5 patients achieving complete response, 31 partial response, 15 stable disease, and 1 progressive disease. Median follow-up duration was 1913 days with a range of 145-2632 days. Of 52 patients, 50 underwent radical hysterectomy after neoadjuvant chemotherapy. The 2-year overall survival rate was 81.8 % for stage IB2, 85.7 % for stage IIA2, and 92.6 % for stage IIB. The most frequent grade 3 and 4 hematological toxicity was neutropenia, with 43 patients experiencing grade 4 and 11 with grade 3. The nonhematological toxicities were mainly grade 1 or 2 in severity.Neoadjuvant chemotherapy with docetaxel and carboplatin followed by radical hysterectomy may be a useful strategy for patients with non-squamous cell carcinoma of uterine cervix. |
| تدمد: | 1437-7772 1341-9625 |
| DOI: | 10.1007/s10147-016-1010-0 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b413b5e12e7825a94cbb0d99c3f51d87 https://doi.org/10.1007/s10147-016-1010-0 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....b413b5e12e7825a94cbb0d99c3f51d87 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14377772 13419625 |
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| DOI: | 10.1007/s10147-016-1010-0 |