The Correlation of 3D DT-MRI Fiber Disruption with Structural and Mechanical Degeneration in Porcine Myocardium
| العنوان: | The Correlation of 3D DT-MRI Fiber Disruption with Structural and Mechanical Degeneration in Porcine Myocardium |
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| المؤلفون: | Jun Liao, Xiaoyong Yang, Song Zhang, Joseph Chen, Ron McLaughlin, J. Allen Crow, Ali Borazjani, Robert C. Cooper, Wei Chen, Katie B. Mullins |
| المصدر: | Annals of Biomedical Engineering. 38:3084-3095 |
| بيانات النشر: | Springer Science and Business Media LLC, 2010. |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | Swine, Chemistry, Myocardium, Myocardial Infarction, Biomedical Engineering, Infarction, Heart, Degeneration (medical), medicine.disease, Radiography, Tissue Degeneration, Disease Models, Animal, Diffusion Tensor Imaging, Imaging, Three-Dimensional, cardiovascular system, medicine, Animals, Humans, cardiovascular diseases, Myocardial infarction, Tissue mechanics, Fiber, Biomedical engineering, Ionotropic effect, Diffusion MRI |
| الوصف: | Evaluation of structural parameters following a myocardial infarction (MI) is important to assess left ventricular function and remodeling. In this study, we assessed the capability of 3D diffusion tensor magnetic resonance imaging (DT-MRI) to assess tissue degeneration shortly after an MI using a porcine model of infarction. Two days after an induced infarction, hearts were explanted and immediately scanned by a 3T MRI scanner with a diffusion tensor imaging protocol. 3D fiber tracks and clustering models were generated from the diffusion-weighted imaging data. We found in a normal explanted heart that DT-MRI fibers showed a multilayered helical structure, with fiber architecture and fiber density reflecting the integrity of muscle fibers. For infarcted heart explants, we observed either a lack of fibers or disruption of fibers in the infarcted regions. Contours of the disrupted DT-MRI fibers were found to be consistent with the infarcted regions. Both histological and mechanical analysis of the infarcted hearts suggested DT-MRI fiber disruption correlated with altered microstructure and tissue mechanics. The ability of 3D DT-MRI to accurately distinguish viable myocardium from dead myocardium only 2 days post infarct without the use of radioisotopes or ionotropic agents makes it a promising approach to evaluate cardiac damage early post-MI. |
| تدمد: | 1573-9686 0090-6964 |
| DOI: | 10.1007/s10439-010-0073-8 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3f382ac9a87dfb020555fe5022d4c20 https://doi.org/10.1007/s10439-010-0073-8 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....b3f382ac9a87dfb020555fe5022d4c20 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15739686 00906964 |
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| DOI: | 10.1007/s10439-010-0073-8 |