Downstream effects of polypathology on neurodegeneration of medial temporal lobe subregions
| العنوان: | Downstream effects of polypathology on neurodegeneration of medial temporal lobe subregions |
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| المؤلفون: | Edward B. Lee, Jacqueline M. Lane, M P Marcos Rabal, Karthik Prabhakaran, F J Molina Romero, M L Bedard, Maria del Mar Arroyo-Jimenez, David J. Irwin, Laura E.M. Wisse, Emilio Artacho-Pérula, M. D. Tisdall, David A. Wolk, John Q. Trojanowski, M M de Iñiguez de Onzono Martin, Ricardo Insausti, J C Delgado González, Paul A. Yushkevich, M Córcoles Parada, Ranjit Ittyerah, Sadhana Ravikumar, Murray Grossman, Sydney Lim, S Cebada Sánchez, Sandhitsu R. Das, Long Xie, Gabor Mizsei, John A. Detre, Theresa Schuck, C de la Rosa Prieto, M Muñoz Lopez |
| المصدر: | Acta Neuropathologica Communications Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-11 (2021) |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, Male, Pathology, Hippocampus, Plaque, Amyloid, 0302 clinical medicine, Cortex (anatomy), Entorhinal Cortex, Aged, 80 and over, Subiculum, Neurodegenerative Diseases, Neurofibrillary Tangles, Middle Aged, Magnetic Resonance Imaging, Temporal Lobe, DNA-Binding Proteins, medicine.anatomical_structure, alpha-Synuclein, Parahippocampal Gyrus, Female, Tauopathy, Supranuclear Palsy, Progressive, Brodmann area, Adult, Lewy Body Disease, medicine.medical_specialty, tau Proteins, Biology, Pathology and Forensic Medicine, Temporal lobe, 03 medical and health sciences, Cellular and Molecular Neuroscience, Atrophy, Pick Disease of the Brain, Alzheimer Disease, mental disorders, medicine, Humans, RC346-429, CA1 Region, Hippocampal, Aged, Amyloid beta-Peptides, Research, Entorhinal cortex, medicine.disease, Brain Cortical Thickness, 030104 developmental biology, Case-Control Studies, Neurology. Diseases of the nervous system, Neurology (clinical), Frontotemporal Lobar Degeneration, 030217 neurology & neurosurgery |
| الوصف: | The medial temporal lobe (MTL) is a nidus for neurodegenerative pathologies and therefore an important region in which to study polypathology. We investigated associations between neurodegenerative pathologies and the thickness of different MTL subregions measured using high-resolution post-mortem MRI. Tau, TAR DNA-binding protein 43 (TDP-43), amyloid-β and α-synuclein pathology were rated on a scale of 0 (absent)—3 (severe) in the hippocampus and entorhinal cortex (ERC) of 58 individuals with and without neurodegenerative diseases (median age 75.0 years, 60.3% male). Thickness measurements in ERC, Brodmann Area (BA) 35 and 36, parahippocampal cortex, subiculum, cornu ammonis (CA)1 and the stratum radiatum lacunosum moleculare (SRLM) were derived from 0.2 × 0.2 × 0.2 mm3 post-mortem MRI scans of excised MTL specimens from the contralateral hemisphere using a semi-automated approach. Spearman’s rank correlations were performed between neurodegenerative pathologies and thickness, correcting for age, sex and hemisphere, including all four proteinopathies in the model. We found significant associations of (1) TDP-43 with thickness in all subregions (r = − 0.27 to r = − 0.46), and (2) tau with BA35 (r = − 0.31) and SRLM thickness (r = − 0.33). In amyloid-β and TDP-43 negative cases, we found strong significant associations of tau with ERC (r = − 0.40), BA35 (r = − 0.55), subiculum (r = − 0.42) and CA1 thickness (r = − 0.47). This unique dataset shows widespread MTL atrophy in relation to TDP-43 pathology and atrophy in regions affected early in Braak stageing and tau pathology. Moreover, the strong association of tau with thickness in early Braak regions in the absence of amyloid-β suggests a role of Primary Age-Related Tauopathy in neurodegeneration. Supplementary Information The online version contains supplementary material available at 10.1186/s40478-021-01225-3. |
| تدمد: | 2051-5960 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3e2d522d56bff8280724b1601fd9d0e https://pubmed.ncbi.nlm.nih.gov/34289895 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....b3e2d522d56bff8280724b1601fd9d0e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20515960 |
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