Cholesterol modulates LRP5 expression in the vessel wall
| العنوان: | Cholesterol modulates LRP5 expression in the vessel wall |
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| المؤلفون: | Lina Badimon, July Carolina Romero, Maria Borrell-Pages |
| المصدر: | ATHEROSCLEROSIS r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau instname |
| بيانات النشر: | ELSEVIER IRELAND LTD, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | medicine.medical_specialty, LRP5, Hypercholesterolemia, Wnt pathway, Hyperlipidemias, Biology, Plant sterol esters, Cholesterol, Dietary, chemistry.chemical_compound, Downregulation and upregulation, Oral administration, medicine.artery, Internal medicine, Hyperlipidemia, medicine, Animals, Receptor, Wnt Signaling Pathway, Aorta, Cholesterol, Macrophages, Wnt signaling pathway, Phytosterols, medicine.disease, Atherosclerosis, Plaque, Atherosclerotic, Mice, Inbred C57BL, Endocrinology, Low Density Lipoprotein Receptor-Related Protein-5, chemistry, Dietary Supplements, Cardiology and Cardiovascular Medicine |
| الوصف: | Objective: Macrophages are key players in atherosclerotic lesion formation and progression. We have recently demonstrated that lipid-loaded macrophages show activation of the canonical Wnt signaling pathway. Methods: To test the in vivo role of the canonical Wnt pathway in atherosclerosis we used mice deficient in the Wnt signaling receptor LRP5 (LRP5(-/-)) fed a hypercholesterolemic diet (HC) to induce atherosclerosis. These dietary groups were further subdivided into two subgroups receiving their respective diets supplemented with 2% plant sterol esters (PSE). All mice remained on their assigned diets until age 18 weeks. Results: HC WT mice had mildly increased non-HDL cholesterol levels, developed aortic atherosclerotic lesions and showed upregulated expression levels of aortic Lrp5. HC LRP5(-/-) mice develop larger aortic atherosclerotic lesions than WT mice indicating that LRP5 has a protective function in atherosclerosis progression. The oral administration of PSE, a dietary cholesterol-lowering agent, had an effect in the expression levels of the Wnt signaling receptor and in atherosclerosis progression. We found that PSE reduced serum total cholesterol levels, abolished HC-induced LRP5 overexpression and reduced aortic atherosclerotic plaques. Conclusion: The proatherogenic effects of the excess of plasma lipids are in part mediated by modulation of LRP5 in the aorta. LRP5 and canonical Wnt signaling exert a protective defense mechanism against hyperlipidemia and atherosclerosis lesion progression. (C) 2014 Elsevier Ireland Ltd. All rights reserved. |
| تدمد: | 0021-9150 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b36545241e77be42fbdf12747584d8b8 https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=8708 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....b36545241e77be42fbdf12747584d8b8 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 00219150 |
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