Diabetes and CVD risk during angiotensin-converting enzyme inhibitor or angiotensin II receptor blocker treatment in hypertension: a study of 15 990 patients
| العنوان: | Diabetes and CVD risk during angiotensin-converting enzyme inhibitor or angiotensin II receptor blocker treatment in hypertension: a study of 15 990 patients |
|---|---|
| المؤلفون: | Sverre E. Kjeldsen, Niklas Hammar, Johan Bodegard, Lars Pål Hasvold, Jan Stålhammar, David Russell, Johan Sundström, Marcus Thuresson |
| المصدر: | Journal of Human Hypertension |
| بيانات النشر: | Springer Science and Business Media LLC, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Angiotensin receptor, Time Factors, Tetrazoles, Angiotensin-Converting Enzyme Inhibitors, Blood Pressure, Type 2 diabetes, Pharmacology, Lower risk, Enalapril, Risk Factors, Internal medicine, Diabetes mellitus, Internal Medicine, medicine, Humans, Cardiac and Cardiovascular Systems, cardiovascular diseases, Aged, Retrospective Studies, Sweden, Kardiologi, Primary Health Care, biology, business.industry, Incidence, Biphenyl Compounds, Hazard ratio, Angiotensin-converting enzyme, Middle Aged, medicine.disease, Candesartan, Treatment Outcome, Diabetes Mellitus, Type 2, Cardiovascular Diseases, Hypertension, biology.protein, Benzimidazoles, Female, Original Article, business, Angiotensin II Type 1 Receptor Blockers, medicine.drug |
| الوصف: | Differences in clinical effectiveness between angiotensin-converting enzyme inhibitors (ACEis) and angiotensin receptor blockers (ARBs) in the primary treatment of hypertension are unknown. The aim of this retrospective cohort study was to assess the prevention of type 2 diabetes and cardiovascular disease (CVD) in patients treated with ARBs or ACEis. Patients initiated on enalapril or candesartan treatment in 71 Swedish primary care centers between 1999 and 2007 were included. Medical records data were extracted and linked with nationwide hospital discharge and cause of death registers. The 11 725 patients initiated on enalapril and 4265 on candesartan had similar baseline characteristics. During a mean follow-up of 1.84 years, 36 482 patient-years, the risk of new diabetes onset was lower in the candesartan group (hazard ratio (HR) 0.81, 95% confidence interval (CI) 0.69-0.96, P = 0.01) compared with the enalapril group. No difference between the groups was observed in CVD risk (HR 0.99, 95% CI 0.87-1.13, P = 0.86). More patients discontinued treatment in the enalapril group (38.1%) vs the candesartan group (27.2%). In a clinical setting, patients initiated on candesartan treatment had a lower risk of new-onset type 2 diabetes and lower rates of drug discontinuation compared with patients initiated on enalapril. No differences in CVD risk were observed. |
| وصف الملف: | application/pdf |
| تدمد: | 1476-5527 0950-9240 |
| DOI: | 10.1038/jhh.2014.43 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3602ff72ea473cad15f64351d5a9ecf https://doi.org/10.1038/jhh.2014.43 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....b3602ff72ea473cad15f64351d5a9ecf |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14765527 09509240 |
|---|---|
| DOI: | 10.1038/jhh.2014.43 |