General synovitis score and immunologic synovitis score reflect clinical disease activity in patients with advanced stage rheumatoid arthritis
| العنوان: | General synovitis score and immunologic synovitis score reflect clinical disease activity in patients with advanced stage rheumatoid arthritis |
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| المؤلفون: | Andreas Niemeier, Tobias Schmidt, Aurélie Najm, Wolfgang Rüther, Rolf D. Burghardt, Nicola Oehler, Haider Mussawy, Veit Krenn |
| المصدر: | Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019) Scientific Reports |
| بيانات النشر: | Nature Publishing Group, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Adult, Male, 0301 basic medicine, medicine.medical_specialty, CD3 Complex, Biopsy, medicine.medical_treatment, Lewis X Antigen, lcsh:Medicine, Synovectomy, Severity of Illness Index, Gastroenterology, Article, Arthritis, Rheumatoid, 03 medical and health sciences, Medical research, 0302 clinical medicine, Synovitis, Internal medicine, Synovial Fluid, medicine, Humans, Rheumatoid arthritis, lcsh:Science, Aged, Inflammation, CD20, Multidisciplinary, biology, CD68, business.industry, Macrophages, lcsh:R, Middle Aged, medicine.disease, Arthroplasty, 030104 developmental biology, Gene Expression Regulation, Prednisolone, biology.protein, Female, Methotrexate, lcsh:Q, business, 030217 neurology & neurosurgery, medicine.drug |
| الوصف: | The purpose of this study was to investigate the relationship between clinical disease activity in patients with advanced stage rheumatoid arthritis (RA) on treatment with Disease Modifying Antirheumatic Drugs (DMARDs) and histopathological scores of synovial inflammation. To this end, synovial biopsies of 62 RA patients who underwent surgery for either synovectomy or total joint arthroplasty were assessed by a general synovitis score (GSS) and an immunologic synovitis score (IMSYC). The clinical disease activity index (CDAI) was significantly correlated with both the GSS and the IMSYC (r = 0.65, p = |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2045-2322 |
| DOI: | 10.1038/s41598-019-44895-9 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b33d0ad87817a28584430765d8b66a55 http://link.springer.com/article/10.1038/s41598-019-44895-9 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....b33d0ad87817a28584430765d8b66a55 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20452322 |
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| DOI: | 10.1038/s41598-019-44895-9 |