Astragaloside IV alleviates liver injury in type 2 diabetes due to promotion of AMPK/mTOR-mediated autophagy
| العنوان: | Astragaloside IV alleviates liver injury in type 2 diabetes due to promotion of AMPK/mTOR-mediated autophagy |
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| المؤلفون: | Yan Li, Xianan Dong, Weiping Li, Yuli Han, Yong Su, Yunfeng Zhu, Jie Zhang, Weizu Li, Yanhua Zhang |
| المصدر: | Molecular Medicine Reports |
| بيانات النشر: | D.A. Spandidos, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, AMPK, Male, Cancer Research, endocrine system diseases, Type 2 diabetes, Pharmacology, AMP-Activated Protein Kinases, medicine.disease_cause, Biochemistry, Rats, Sprague-Dawley, 0302 clinical medicine, Glucose homeostasis, Homeostasis, Liver injury, TOR Serine-Threonine Kinases, Articles, Astragalus propinquus, Oncology, Liver, 030220 oncology & carcinogenesis, mTOR, Molecular Medicine, autophagy, Diet, High-Fat, Streptozocin, Diabetes Mellitus, Experimental, 03 medical and health sciences, Insulin resistance, Genetics, medicine, AS-IV, Animals, Molecular Biology, business.industry, Autophagy, nutritional and metabolic diseases, Saponins, medicine.disease, Triterpenes, Rats, Oxidative Stress, 030104 developmental biology, Glucose, Diabetes Mellitus, Type 2, Quality of Life, Liver function, diabetic liver injury, Insulin Resistance, business, Oxidative stress |
| الوصف: | Diabetic liver injury is a serious complication of type 2 diabetes mellitus (T2DM), which is often irreversible in the later stage, and affects the quality of life. Autophagy serves an important role in the occurrence and development of diabetic liver injury. For example, it can improve insulin resistance (IR), dyslipidaemia, oxidative stress and inflammation. Astragaloside IV (AS-IV) is a natural saponin isolated from the plant Astragalus membranaceus, which has comprehensive pharmacological effects, such as anti-oxidation, anti-inflammation and anti-apoptosis properties, as well as can enhance immunity. However, whether AS-IV can alleviate diabetic liver injury in T2DM and its underlying mechanisms remain unknown. The present study used high-fat diets combined with low-dose streptozotocin to induce a diabetic liver injury model in T2DM rats to investigate whether AS-IV could alleviate diabetic liver injury and to identify its underlying mechanisms. The results demonstrated that AS-IV treatment could restore changes in food intake, water intake, urine volume and body weight, as well as improve liver function and glucose homeostasis in T2DM rats. Moreover, AS-IV treatment promoted suppressed autophagy in the liver of T2DM rats and improved IR, dyslipidaemia, oxidative stress and inflammation. In addition, AS-IV activated adenosine monophosphate-activated protein kinase (AMPK), which inhibited mTOR. Taken together, the present study suggested that AS-IV alleviated diabetic liver injury in T2DM rats, and its mechanism may be associated with the promotion of AMPK/mTOR-mediated autophagy, which further improved IR, dyslipidaemia, oxidative stress and inflammation. Thus, the regulation of autophagy may be an effective strategy to treat diabetic liver injury in T2DM. |
| اللغة: | English |
| تدمد: | 1791-3004 1791-2997 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b337f1540f2f1500496cf9f5e4615ab1 http://europepmc.org/articles/PMC8060804 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....b337f1540f2f1500496cf9f5e4615ab1 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17913004 17912997 |
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